Results 51 to 60 of about 13,953,309 (254)

Ambulatory blood pressure and endothelium-dependent vasodilation in hypertensive patients

, 2000
Endothelial function is important for local vascular regulation and an abnormal endothelium-dependent vasodilatation (EDV) has been observed in subjects with essential hypertension.
von zur Mühlen, Bengt,, Lind, Lars,, Millgård, Jonas,, Sarabi, Mahziar,   +3 more
core   +1 more source

Blood pressure control for diabetic retinopathy

São Paulo Medical Journal
BACKGROUND: Diabetic retinopathy is a common complication of diabetes and a leading cause of visual impairment and blindness. Research has established the importance of blood glucose control to prevent development and progression of the ocular ...
Diana V. Do, Xue Wang, Satyanarayana S. Vedula, Michael Marrone, Gina Sleilati, Barbara S. Hawkins, Robert N. Frank   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Optimizing blood pressure control through the use of fixed combinations

Vascular Health and Risk Management, 2010
Rainer DüsingMedizinische Klinik und Poliklinik 1, Bonn, GermanyAbstract: The majority of hypertensive patients need ≥2 antihypertensive agents to reach goal blood pressure.
Rainer Düsing
doaj  

Blood pressure control in anticoagulated hypertensive patients

, 2015
Objective To compare the methods of office blood pressure (BP) measurement and ambulatory blood pressure monitoring (ABPM) to ensure optimal BP control in hypertensive anticoagulated patients.
Güzet, Feza, Bitigen, Atilla, Çimen, Arif Oğuzhan, Teyfik, Nihal, Karabay, Can Yücel   +4 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Kumari, Meena, Hoti, Mimoza, Samani, NJ, Peeter Juhanson, Elliott Paul, C. Ji (7611359), M. Marmot (7611368), Anna F Dominiczak, Juhanson, P, Marmot, Michael, Connell, JM, Philip Howard, Shaw Hawkins, Sue, Kumari Meena, P. B. Munroe (7602386), J. Chambers (3846385), Veldre, G, Farrall, Martin, Connell John M., Pasquale Strazzullo, John Chambers, Marmot Michael, Dobson, R, Kumari, M, Burke, Beverley, Samani Nilesh J., Brown, M. J. (Morris Jonathan), Morris Brown, Newhouse, Stephen; id_orcid, Elliott, Paul, Gudrun Veldre, Shaw-Hawkins, Sue, B. Burke (7611347), Strazzullo, P, Dobson, Richard; id_orcid, R. Collins (7159586), Iacone, Roberto, Cappuccio, Francesco P., Laan, Maris, Lathrop, G. Mark, Kooner, Jaspal, Munroe, Patricia B., Clarke, R, Beverley Burke, Brunner, Eric, P. Strazzullo (7611365), Farrall Martin, Viigimaa Margus, Brown, M, Lee, Kate, Hoti, M, Samani, Nilesh J., Francesco P Cappuccio, Newhouse Stephen, P. Howard (7611350), Richard Dobson, S. Newhouse (6642536), Juhanson Peeter, Elliott, P, Org, E, Nilesh J. Samani (7579793), Farrall, M, Burke Beverley, Lathrop G. Mark, Paul Elliott, Newhouse, S, Veldre, Gudrun, E. Org (7602644), Wallace Chris, Burke, B, Caulfield, Mark, Chambers, John, Marmot, Michael G., Martin Farrall, John M Connell, Onipinla Abiodun, Hoti Mimoza, M. Laan (7602659), Maris Laan, Dominiczak, AF, J. M. Connell (7602551), M. Viigimaa (7602620), Cappuccio Francesco P., Cappuccio, FP, Newhouse, Stephen, Onipinla, A, Kate Lee, Shaw-Hawkins Sue, Susana Eyheramendy, Iacone Roberto, Marmot, M, C. Wallace (7602467), Munroe, PB, Brown, Morris, Jaspal Kooner, Wallace, C, M. Farrall (6522599), Dominiczak Anna F., S. Eyheramendy (7611197), Roberto Iacone, Caulfield, M, Eric Brunner, Lee, K, Chris Wallace, Strazzullo Pasquale, Brunner Eric, M. Brown (3020991), G. M. Lathrop (7611353), Collins Rory, G Mark Lathrop, Juhanson, Peeter, Ji Chen, Meena Kumari, Howard Philip, Cappuccio, Francesco, Chambers, John, MD, Org, Elin, Caulfield Mark, K. Lee (1769563), E. Brunner (7611371), Lathrop, GM, S. Shaw-Hawkins (7602380), Org Elin, Chambers John, Iacone, R, Brunner, E, Margus Viigimaa, F. P. Cappuccio (7611356), Wallace, Chris, P. Elliott (1293702), Viigimaa, Margus, R. Dobson (6375266), A. F. Dominiczak (7602482), Chen Ji, Connell, John M., Connell, J. M. C., Sue Shaw-Hawkins, Dobson, Richard, Munroe Patricia B., Clarke, Robert, Eyheramendy, S, Rory Collins, Patricia B Munroe, Howard, P, M. Caulfield (7609097), Eyheramendy, Susana, Collins, Rory, Dobson Richard, Veldre Gudrun, Mimoza Hoti, Stephen Newhouse, Collins, R, M. Hoti (7611344), Laan Maris, Elin Org, Robert Clarke, Ji, C, Viigimaa, M, Shaw-Hawkins, S, Onipinla, Abiodun, Michael Marmot, Dominiczak, A. F., Mark Caulfield, R. Iacone (7611362), Abiodun Onipinla, G. Veldre (7602656), Clarke Robert, Eyheramendy Susana, A. Onipinla (7602377), M. Kumari (7602503), Kooner Jaspal, P. Juhanson (7602641), Nilesh J Samani, Dominiczak, Anna F., Lee Kate, Chambers, J, Strazzullo, Pasquale, Howard, Philip, Ji, Chen, Kooner, J, Brown Morris, J. Kooner (7609340), R. Clarke (7602407), Laan, M   +183 more
core   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source