Results 61 to 70 of about 20,517 (214)

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

HEMOPHILIA PATIENT WITH DIFFICULTY IN BLOOD PRESSURE CONTROL

Sanamed, 2018
Hypertension prevalence is increasing in patients with hemophilia. Therefore it is an important complication of hemophilia. We aimed to present a 49-year-old male patient with hemophilia-A who presented with acute hemarthrosis and hypertensive attack ...
Ugur Mehmet Can, Atabay Yusuf, Akar Harun   +2 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Parenteral clevidipine for the acute control of blood pressure in the critically ill patient: a review

Therapeutics and Clinical Risk Management, 2009
W Frank Peacock IV1, Jorge E Angeles2, Karina M Soto2, Philip D Lumb3,  Joseph Varon41The Cleveland Clinic, Cleveland, OH, USA; 2Universidad Autónoma de Baja California, Facultad de Medicina, Tijuana, M&eacute ...
W Frank Peacock IV, Jorge E Angeles, Karina M Soto, et al   +3 more
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effects of efforts to intensify management on blood pressure control among patients with type 2 diabetes mellitus and hypertension: A pilot study

Vascular Health and Risk Management, 2009
Ramona S DeJesus1, Rajeev Chaudhry1, Dorinda J Leutink2, Melanie A Hinton1, Stephen S Cha3, Robert J Stroebel11Division of Primary Care Internal Medicine, 2Quality Management Services, 3Division of Biomedical Statistics and Informatics, Mayo Clinic ...
Ramona S DeJesus, Rajeev Chaudhry, Dorinda J Leutink, et al   +3 more
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Predictors of poor blood pressure control assessed by 24 hour monitoring in patients with type B acute aortic dissection

Vascular Health and Risk Management, 2012
Pascal Delsart1, Marco Midulla2, Jonathan Sobocinski3, Charles Achere4, Stephan Haulon3, Gonzague Claisse1, Claire Mounier-Vehier11Vascular Medicine and Hypertension Department, Cardiology Hospital, CHRU Lille, 2Radiology and Cardiovascular Imaging ...
Delsart P, Midulla M, Sobocinski J, Achere C, Haulon S, Claisse G, Mounier-Vehier C   +6 more
doaj  

Team-Based Hypertension Management to Improve Blood Pressure Control

Journal of Primary Care & Community Health, 2016
Objective: Hypertension is the most common condition seen in primary care, occurring in 1 in 3 adults in the United States. The patient-centered medical home provides an opportunity for proactive, team-based care of hypertension.
Jeffrey D. Kravetz, Robert F. Walsh
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source