Results 221 to 230 of about 477,507 (338)

Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance. [PDF]

Front Immunol
Liang S, Xu W, Zhong P, Tao C, Zhang L, Jia C.   +5 more
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Cloning and enhancing lumbrokinase production from local Eisenia fetida by signal peptide engineering for effective thrombosis treatment. [PDF]

PLoS One
Tabassum A, Zeeshan N, Afroz A.
europepmc   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Molecular Genetic Analysis of a <i>DMD</i> Frameshift Mutation in a Boy with Duchenne Muscular Dystrophy by MLPA and Sanger Sequencing. [PDF]

Pharmgenomics Pers Med
Chen Q, Zhang W, Zha L.
europepmc   +1 more source

Coactosin‐Like Protein Reduces Prostaglandin D2 Production in Alveolar Macrophages and Alleviates Allergic Airway Inflammation

Advanced Science, EarlyView.
Coactosin‐like protein inhibits prostaglandin D₂ (PGD2) secretion by modulating alveolar macrophage polarization, thereby suppressing activation of the PGD2 receptor CRTH2 in Th2‐associated immune cells and alleviating allergic airway inflammation.
Li‐Long Pan, Zhengnan Ren, Binbin Li, Wenjie Liang, Yang Luo, Qin Yang, He Liu, Xiaoliang Dong, Haizhi Tian, Huimin Zou, Bengt Samuelsson, Olof Rådmark, Jia Sun   +12 more
wiley   +1 more source

Weaning as Stressor for Calf Welfare. [PDF]

Animals (Basel)
Guasco C, Moriconi M, Vitale N, Fusi F, Schleicherová D, Razzuoli E, Vevey M, Bergagna S.   +7 more
europepmc   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

Idiopathic Fibrillary Glomerulonephritis: A Case Report Highlighting Diagnostic and Management Challenges. [PDF]

Cureus
Gayibov E, Gupta I.
europepmc   +1 more source