Results 231 to 240 of about 1,056,334 (396)

An Off‐the‐Shelf Artificial Proregenerative Macrophage for Pressure Ulcer Treatment

Advanced Science, EarlyView.
Artificial macrophages (artM) by encapsulating M2 lysates into biodegradable PLGA microspheres and coated with macrophage membrane, are engineered as new therapeutics against skin pressure ulcer. In mouse models, the artM exhibited robust tissue repair through cell recruitment and microenvironment modulation, showing great therapeutic potential for ...
Qi Su, Jingrong Wang, Yini Huangfu, Rui Gao, Pengxu Kong, Yu Gao, Huijuan Song, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Zujian Feng, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

High-Risk Nonsecretory Multiple Myeloma With Poor Response to Daratumumab-Based Chemotherapy. [PDF]

Cureus
Khanal S, Rizvi R, March C.
europepmc   +1 more source

Targeting PTBP3‐Mediated Alternative Splicing of COX11 Induces Cuproptosis for Inhibiting Gastric Cancer Peritoneal Metastasis

Advanced Science, EarlyView.
The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou, Chao Dong, Xiaochun Shen, Pengbo Wang, Tao Chen, Weikang Li, Xiaotong Sun, Peiyuan Li, Chengxiang Xu, Kaipeng Duan, Dongbao Li, Jin Zhou   +11 more
wiley   +1 more source

Deciphering Acute Coronary Syndromes Pathobiology Through Proteomics. [PDF]

J Cardiovasc Dev Dis
Nieddu G, Formato M, Lepedda AJ.
europepmc   +1 more source

Biogenesis of Organelles and Membrane Proteins. [PDF]

, 1988
Harmey, Matthew A., Neupert, Walter, Nicholson, Donald W., Stuart, Rosemary A.   +3 more
core   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Sheep immune response against a novel recombinant enterotoxemia and infectious necrotic hepatitis vaccine in Türkiye. [PDF]

BMC Vet Res
Ekinoğlu DN, Çelik V, Gül E, Kalender H, Öngör H, Çetinkaya B.   +5 more
europepmc   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Changes in blood serum protein profile in low-yielding ewes during the periparturient period. [PDF]

Open Vet J
Glembová V, Tóthová C, Oršuľaková V, Nagy O.   +3 more
europepmc   +1 more source

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source