Results 161 to 170 of about 2,295,600 (306)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Beyond cell-cell adhesion: Emerging roles of the tight junction scaffold ZO-2 [PDF]

, 2013
Gehwolf, R., Krizbai, István Adorján, Toepfer, S., Traweger, A., Wagner, R.N., Wilhelm, Imola, Zweimueller-Mayer, J.   +6 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Ambient temperature exposure on inflammatory blood proteins-A longitudinal self-sampling survey in young Swedish adults. [PDF]

iScience
Yu Z, Björkander S, Bendes A, Nobile F, Zhang J, Merid SK, Hernandez-Pacheco N, He S, Kere MM, Klevebro S, Ljungman P, Stafoggia M, Bellander T, Pershagen G, Bergström A, Kull I, Merritt AS, Roxhed N, Gruzieva O, Schwenk JM, Melén E.   +20 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Catalytically Active Recombinant Cysteine Proteases of <i>Haemonchus contortus:</i> Their Ability to Degrade Host Blood Proteins and Modulate Coagulation. [PDF]

Int J Mol Sci
Karunakaran AC, Bakshi M, Rajendrakumar AM, Wilson-Welder JH, Aroian RV, Schwarz EM, Homan EJ, Ostroff GR, Beshah E, Miramontes E, Papadopoulos MD, Bowdridge SA, Zarlenga DS, Zhu X, Tuo W.   +14 more
europepmc   +1 more source

Hydrolysis Conditions of Porcine Blood Proteins and Antimicrobial Effects of Their Hydrolysates. [PDF]

Food Sci Anim Resour, 2020
Jin SK, Choi JS, Yim DG.
europepmc   +1 more source

COVID-19 coagulopathies: Human blood proteins mimic SARS-CoV-2 virus, vaccine proteins and bacterial co-infections inducing autoimmunity: Combinations of bacteria and SARS-CoV-2 synergize to induce autoantibodies targeting cardiolipin, cardiolipin-binding proteins, platelet factor 4, prothrombin, and coagulation factors. [PDF]

Bioessays, 2021
Root-Bernstein R.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative In Silico and Experimental Strategy. [PDF]

Foods
Tan J, Huang S, Wu D, Zhao Z, Zhao Y, Fu Y, Wu W.   +6 more
europepmc   +1 more source