Host blood proteins as bridging ligand in bacterial aggregation as well as anchor point for adhesion in the molecular pathogenesis of Staphylococcus aureus infections. [PDF]
Casillas-Ituarte NN +4 more
europepmc +1 more source
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XV. THE PROTEINS CONCERNED IN THE BLOOD COAGULATION MECHANISM 12 [PDF]
John T. Edsall +2 more
openalex +1 more source
Blood coagulation control proteins.
血液凝固と凝固制御反応は,正常時における血液の流動性の維持と傷害時における止血と組織修復に不可欠な生体防御反応である.最近の臨床研究により,血栓形成の制御・調節における凝固制御蛋白の重要性が明らかになってきた.凝固制御蛋白の作用機序は多様で, 1)プロテアーゼとして作用して凝固因子を分解する(プロテインC), 2)補酵素蛋白として作用してプロテアーゼの活性を高める(トロンボモジュリン,プロテインS), 3)プロテアーゼインヒビターとして作用して活性化凝固因子を阻害する(アンチトロンビンIII,組織因子系凝固インヒビター)などがある.これらの蛋白は血小板や血管内皮などの細胞膜リン脂質や細胞膜上のヘパリン様物質に結合して活性発現する.本稿では,生理的に重要な凝固制御蛋白の構造と機能の関係 ...
openaire +2 more sources
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa +14 more
wiley +1 more source
AMINO-ACIDS OF THE BLOOD AS THE PRECURSORS OF MILK PROTEINS
C. A. Cary
openalex +1 more source
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source
THE NON-PROTEIN ORGANIC CONSTITUENTS IN THE BLOOD OF MARINE FISH
W. Denis
openalex +1 more source
The conversion of cyanogen chloride to cyanide in the presence of blood proteins and sulphydryl compounds [PDF]
W. N. Aldridge
openalex +1 more source
Sarah A. Lynch +3 more
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source

