Results 191 to 200 of about 2,314,484 (362)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Ambient temperature exposure on inflammatory blood proteins-A longitudinal self-sampling survey in young Swedish adults. [PDF]

iScience
Yu Z, Björkander S, Bendes A, Nobile F, Zhang J, Merid SK, Hernandez-Pacheco N, He S, Kere MM, Klevebro S, Ljungman P, Stafoggia M, Bellander T, Pershagen G, Bergström A, Kull I, Merritt AS, Roxhed N, Gruzieva O, Schwenk JM, Melén E.   +20 more
europepmc   +1 more source

Hydrolysis Conditions of Porcine Blood Proteins and Antimicrobial Effects of Their Hydrolysates. [PDF]

Food Sci Anim Resour, 2020
Jin SK, Choi JS, Yim DG.
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Catalytically Active Recombinant Cysteine Proteases of <i>Haemonchus contortus:</i> Their Ability to Degrade Host Blood Proteins and Modulate Coagulation. [PDF]

Int J Mol Sci
Karunakaran AC, Bakshi M, Rajendrakumar AM, Wilson-Welder JH, Aroian RV, Schwarz EM, Homan EJ, Ostroff GR, Beshah E, Miramontes E, Papadopoulos MD, Bowdridge SA, Zarlenga DS, Zhu X, Tuo W.   +14 more
europepmc   +1 more source

Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort. [PDF]

Genome Med, 2020
Zhong W, Gummesson A, Tebani A, Karlsson MJ, Hong MG, Schwenk JM, Edfors F, Bergström G, Fagerberg L, Uhlén M.   +9 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative <i>In Silico</i> and Experimental Strategy. [PDF]

Foods
Tan J, Huang S, Wu D, Zhao Z, Zhao Y, Fu Y, Wu W.   +6 more
europepmc   +1 more source

Electrochemical sensing of blood proteins for mild traumatic brain injury (mTBI) diagnostics and prognostics: towards a point-of-care application. [PDF]

RSC Adv, 2021
Pankratova N, Jović M, Pfeifer ME.
europepmc   +1 more source