Results 191 to 200 of about 11,399,320 (390)

Blood coagulation control proteins.

open access: yesNihon Naika Gakkai Zasshi, 1994
血液凝固と凝固制御反応は,正常時における血液の流動性の維持と傷害時における止血と組織修復に不可欠な生体防御反応である.最近の臨床研究により,血栓形成の制御・調節における凝固制御蛋白の重要性が明らかになってきた.凝固制御蛋白の作用機序は多様で, 1)プロテアーゼとして作用して凝固因子を分解する(プロテインC), 2)補酵素蛋白として作用してプロテアーゼの活性を高める(トロンボモジュリン,プロテインS), 3)プロテアーゼインヒビターとして作用して活性化凝固因子を阻害する(アンチトロンビンIII,組織因子系凝固インヒビター)などがある.これらの蛋白は血小板や血管内皮などの細胞膜リン脂質や細胞膜上のヘパリン様物質に結合して活性発現する.本稿では,生理的に重要な凝固制御蛋白の構造と機能の関係 ...
openaire   +2 more sources

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

open access: yesMolecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa   +14 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

Harnessing the Potential of Blood Proteins as Functional Ingredients: A Review of the State of the Art in Blood Processing.

open access: yesComprehensive Reviews in Food Science and Food Safety, 2017
Sarah A. Lynch   +3 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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