Results 81 to 90 of about 1,574,624 (315)

Red Blood Cells: Chasing Interactions

Frontiers in Physiology, 2019
Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and most intracellular machineries during their maturation process.
Virginia Pretini, Virginia Pretini, Mischa H. Koenen, Lars Kaestner, Lars Kaestner, Marcel H. A. M. Fens, Raymond M. Schiffelers, Marije Bartels, Richard Van Wijk   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Proteins as markers of TSE infection in sheep blood

, 2008
Transmissible spongiform encephalopathies (TSEs) are a group of fatal infectious neurodegenerative diseases affecting both humans and agricultural animals. TSE transmission via blood transfusion has been demonstrated experimentally in rodent, primate and
Martin, Joanne
core  

Proteins from blood

, 2022
S.323-329Blood is the most important byproduct of slaughtering; it consists predominantly of protein and water, and is a valuable protein resource. The protein content in blood from domestic meat animals is equivalent to 6-7 percent of the lean meat ...
Kobald, M.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Timing and modality of the sclerosing agents binding to the human proteins: laboratory analysis and clinical evidences

Veins and Lymphatics, 2014
Sclerosing agents (SA) are blood inactivated. Nevertheless, investigations concerning the interaction among SA and blood components have never been deeply investigated.
Lorenzo Tessari, Marcello Izzo, Attilio Cavezzi, Francesco Zini, Mirko Tessari, Mario Ambrosino, Roberto Fanelli   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SecScan:a general approach for mapping disulfide bonds in synthetic and recombinant peptides and proteins

, 2019
Selenocysteine scanning (SecScan) is a novel technique to map disulfide networks in proteins independent of structure-based distance information and mass spectrometry.
Hackeng, Tilman M.; id_orcid, Denisov, Stepan S., Ippel, Johannes H., Dijkgraaf, Ingrid; id_orcid, Mans, Ben J., Dijkgraaf, Ingrid, Hackeng, Tilman M.   +6 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells

, 2014
Thrombin is the key serine protease of the coagulation cascade and a potent trigger of protease-activated receptor (PAR)1-mediated platelet aggregation. In recent years, PAR1 has become an appealing target for anticoagulant therapies.
Pharmaceutics, Meijer, Alexander B, van den Eshof, Bart L., Neilson, Lisa J, Sub Pharmaceutical proteins, van den Biggelaar, Maartje, Hernández-Fernaud, Juan Ramon, Mertens, Koenraad, Mertens, Koen, van den Eshof, Bart L, Neilson, Lisa J., Zanivan, Sara, Meijer, Alexander B.   +12 more
core   +1 more source