Results 101 to 110 of about 1,574,624 (315)

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria [PDF]

, 2004
Background<br/><br/> Mutations in the gene coding for the RNA component of telomerase, hTERC, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia.
Ulku, B., Bessler, M., Bilsland, A., Mason, Philip J, Vulliamy, T., Serakinci, Nedime, Dokal, I., Ar, C., Ar, C, Marrone, Anna, Dokal, Inderjeet, Ulku, B, Bessler, Monica, Erzik, C, Serakinci, N, Serakinci, N., Marrone, A, Zhao, Jiangqin, Zhao, J, Dokal, I, Bilsland, A, Mason, PJ, Bilsland, Alan, Ulku, Birsen, Keith, W.N., Bessler, M, Vulliamy, T, Vulliamy, Tom, Keith, W Nicol, Erzik, Can, Marrone, A., Erzik, C., Zhao, J., Mason, P.J., Ar, Cem, Keith, WN   +35 more
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Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Blood Pressure and Blood Protein Determinations in the Frog.

Experimental Biology and Medicine, 1928
In a previous note,1 the authors called attention to the low protein content of frog's blood. The low colloidal pressure of the blood is an important factor in determining the production of urine. The blood pressure of the frog is not nearly as high as in mammals, but if filtration is the basis of glomerular activity, there should be enough pressure to
R. N. Bieter, F. H. Scott
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characterization of the Proteins HPIP and VENTX2 as Novel Regulatory Proteins of Human Hematopoiesis [PDF]

, 2006
The hallmark of hematopoietic stem cells (HSC) is their ability of self-renewal and differentiation into multiple hematopoietic cell lineages. Although the molecular network controlling stem cell fate decisions is largely unknown, multiple studies have ...
Arseni, Natalia, Arseni, N.
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Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins [PDF]

, 2012
Basophils are blood cells of low abundance associated with allergy, inflammation and parasite infections. To study the transcriptome of mature circulating basophils cells were purified from buffy coats by density gradient centrifugations and two-step ...
Grundström Jeanette, Grundström, Jeanette, Reimer, JM, Sofia E Magnusson, Sofia E. Magnusson, Nilsson, Gunnar, Hellman, L, Wernersson, Sara, Wernersson, S, Magnusson, SE, Wernersson, Sara,, Nilsson Gunnar, Reimer Jenny M., Sara Wernersson, Grundström, Jeanette,, Jenny M. Reimer, Hellman, Lars,, Hellman, Lars, Wernersson Sara, Jenny M Reimer, Gunnar Nilsson, Nilsson, G,, Lars Hellman, Jeanette Grundström, Magnusson Sofia E., Magnusson, Sofia E., Grundstrom, J, Reimer, Jenny M., Reimer, Jenny M.,, Hellman Lars   +29 more
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Application of interpretable machine learning algorithms to predict macroangiopathy risk in Chinese patients with type 2 diabetes mellitus

Scientific Reports
Macrovascular complications are leading causes of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM), yet early diagnosis of cardiovascular disease (CVD) in this population remains clinically challenging.
Ningjie Zhang, Yan Wang, Hui Zhang, Huilong Fang, Xinyi Li, Zhifen Li, Zhenghang Huan, Zugui Zhang, Yongjun Wang, Wei Li, Zheng Gong   +10 more
doaj   +1 more source

Engineering blood cells and proteins as blood substitutes: A short review [PDF]

Biotechnology and Bioprocess Engineering, 2007
In this brief review, basic principles and recent progresses on the development of therapeutic substitutes for major blood components are briefly discussed with primary focus on the red cell substitutes.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Genetic polymorphism of blood proteins in a population of shetland ponies

, 1976
Genetic variation of proteins (protein polymorphism) is widespread among many animal species. The biological significance of protein polymorphism has been the subject of many studies.
Buis, R.C.
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