Results 121 to 130 of about 2,295,600 (306)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Kinetics-like equation for cerebrospinal fluid-blood diffusion models

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: The diffusion of proteins from the blood to the cerebrospinal fluid is influenced by its molecular weight and by the intrinsic properties and biological properties of the protein. Objective: Determinate the diffusion of new proteins as they
José Alejandro Rodríguez-Pérez, Alejandro Mirabal-Viel, Vanessa Pérez-del-Vallín, Christian Meijides-Mejías, William Castillo-González, Jairo Lumpuy-Castillo, Alberto Juan Dorta-Contreras   +6 more
doaj  

Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials. [PDF]

Int J Mol Sci, 2022
Yamaguchi T, Kim HM, Oh JM.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cross‐Platform Proteomics and Machine Learning Algorithms Nominate Plasma Biomarkers of Stroke Diagnosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Blood‐based biomarkers for stroke subtyping could improve triage in emergency settings. We used cross‐platform proteomics to identify plasma biomarkers differentiating major stroke diagnostic groups.
Shubham Misra, Wooyoung Eric Jang, Sebastian Sanchez, Aditya Natu, Prateek Kumar, Michael Liu, Anmol Kaur, Victor Torres Lopez, Pinar Caglayan, Rolando Garcia‐Milian, Caroline M. Watson, Michael R. Frankel, Guido J. Falcone, Lauren H. Sansing, Srikant Rangaraju   +14 more
doaj   +1 more source

A New method for the capture of surface proteins in Plasmodium falciparum parasitized erythrocyte [PDF]

, 2012
Introduction: We propose a new method for the selective labeling, isolation and electrophoretic analysis of the Plasmodium falciparum protein exposed on the erythrocyte cell surface.
Ferru, Emanuela, Pantaleo, Antonella, Turrini, Francesco Michelangelo   +2 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Alterations in blood proteins in the prodromal stage of bipolar II disorders. [PDF]

Sci Rep, 2022
Lee H, Han D, Rhee SJ, Kim J, Lee Y, Kim EY, Park DY, Roh S, Baik M, Jung HY, Lee J, Lee TY, Kim M, Shin H, Kim H, Kim SH, Kwon JS, Ahn YM, Ha K.   +18 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source