Results 111 to 120 of about 1,574,624 (315)
Identification of salivary gland proteins depleted after blood feeding in the malaria vector Anopheles campestris-like mosquitoes (Diptera: Culicidae).
PLoS ONE, 2014 Malaria sporozoites must invade the salivary glands of mosquitoes for maturation before transmission to vertebrate hosts. The duration of the sporogonic cycle within the mosquitoes ranges from 10 to 21 days depending on the parasite species and ...Sriwatapron Sor-suwan, Narissara Jariyapan, Sittiruk Roytrakul, Atchara Paemanee, Atchara Phumee, Benjarat Phattanawiboon, Nuchpicha Intakhan, Wetpisit Chanmol, Paul A Bates, Atiporn Saeung, Wej Choochote +10 moredoaj +1 more sourceCD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu +8 morewiley +1 more sourceAssociation of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. [PDF]
, 2011 The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA.Keating, BJ, Boehnke, M., Lawrence, Robert W, Ridker, P.M., Alexander, M., Elosua, R., Zukowska-szczechowska, E., Philip Howard, Boerwinkle, E., Dong, Y., Parker, A.N., van der Schouw, Y.T., Hicks, Andrew A, Palmer, L.J., Zukowska-Szczechowska, Ewa, Palmer, N.D., Chris O'Donnell, Mangino, M., Colin A. McKenzie, Milaneschi, Yuri, Yen-Pei C. Chang, Toshiko Tanaka, Young, J. Hunter, Martin, Lisa W., Rettig, Rainer, Sudha Seshadri, Polak, J. F., Lathrop, Mark, Marmot, M. G., Josef F. Polak, Maciej Tomaszewski, Longstreth, Will T, Cooper, Richard S, Hedblad, Bo, Kuznetsova, T., Groop, L., Steve E. Humphries, Cooper, Richard S., Barroso, Inês, Rick Twee-Hee Ong, Cooper, J. A., Yoshikuni Kita, Ong, R.T., Loos, Ruth J F, Hugh Watkins, Vinay, D G, Chambers, John C, Schwartz, Steven M, Tai, E.S., Charles S. Janipalli, Janos Terzic, Mika Ala-Korpela, Altshuler, D., Keating, B., Maris Laan, Hofman, A., Igl, W., Daniel L. Dries, Smith, Albert V, Ongen, Halit, Thomas H. Mosley, Grassler, J., Seielstad, Mark, Heyo K. Kroemer, Miki, T., Vartiainen, Erkki, Steinle, N.I., Markku Laakso, EchoGen consortium, [Unknown], Keating, Brendan J, Ludwig, Barbara, Chang, Yen-Pei C, Bergman, R.N., Salako, T., Brand, E., Iwai, N., Salomaa, Veikko, Joel N. Hirschorn, Collins, Francis S, Go, M.J., Johnson, T, Wichmann, H.- E., Farlow, Deborah N., Hopewell, J. C., Hunt, S.C., Sue Shaw-Hawkins, Kurt K. Lohman, Orru, Marco, Najjar, S., Lehtimäki, Terho, Lori L. Bonnycastle, Tripathy, Vikal, Abbas Dehghan, Solomon K. Musani, Uitterlinden, Andre G, et al., Cuno S.P.M. Uiterwaal, Andrew D. Johnson, Valur Emilsson, Wong, T. Y., Larson, M. G., Mosley, Thomas H, Benjamin F. Voight, Laan, M., Navis, G., Michiel L. Bots, Farlow, D. N., Nalls, M.A., Zhang, W., Rice, K.M., Gyllensten, Ulf B, Mani, K Radha, Wyatt, S. B., Vitart, Veronique, Emilsson, V., Johannes Kettunen, Hercberg, S., Brown, Morris J, Nguyen, Khanh-Dung Hoang, Michael G. Marmot, Rao, D. C., John C. Chambers, Voight, B. F., Franceschini, N, Aravinda Chakravarti, Scuteri, Angelo, Lucas, Gavin, Sun, Y.V., Khanh-Dung Hoang Nguyen, Santhi Ganesh, Dominiczak, Anna F, Caulfield, M.J., Wright, A.F., Talmud, Philippa J, Forrester, Terrence, Kooner, J.S., Robert W. Lawrence, Cooper, M. N., Hadley, D., Gaunt, T.R., Lyon, HN, Fernando Rivadeneira, Jaakko Tuomilehto, Talmud, P.J., Gyllensten, U. B., George Davey Smith, Ulf B. Gyllensten, Lyon, Helen N, Longstreth, W.T., Shih-Jen Hwang, Wareham, N.J., Eaton, C. B., Li, Y., Toshio Ogihara, Kooner, Jaspal S, Giuseppe Matullo, Peter P. Pramstaller, Pihur, V., Steinle, N. I., Burton, P.R., Heath, S., Mariacorsi, A., Verwoert, G. C., Erdmann, Jeanette, Nicholas J. Wareham, Eva Brand, Samani, N. J., Artigas, M.S., Sharma, Pankaj, Xiaofeng Zhu, Galan, P., Li, YL, van Gilst, Wiek H, Van Der Harst, P., Vineis, P., Collins, F.S., Tai, E Shyong, Jackson, A.U., Grässler, Jürgen, Wilson, James F, Palmer, Lyle J, Danish Saleheen, Whincup, P.H., Lee, J.-y., Tukiainen, T., Okamura, T., Garcia, M., Dong, Yanbin, Dorairajan Prabhakaran, Judith A. Hoffman Bolton, Kang, S.J., Casas, J. P., Dehghan, Abbas, Kroemer, H. K., KidneyGen consortium, [Unknown], Penman, Alan D., Bamidele O. Tayo, Melissa Garcia, Verwoert, Germaine C, Perola, Markus, Cristian Pattaro, Köttgen, Anna, Rice, K. M., Alex N. Parker, Vinay, DG, Islam, M., McKenzie, Colin A, Van Der Schouw, Y. T., Toby Johnson, Meschia, James F, Hercberg, Serge, Longstreth, W. T., Pramstaller, P. P., Parker, A. N., Bornstein, S. R., Beckmann, Jacques S, Hicks, A.A., Min JinGo, Volker, U., Susana Eyheramendy, Fox, Ervin R., Hartikainen, A.-l., Will T. Longstreth, Townsend, R.R., Brand, Eva, Jacques S. Beckmann, Anna-Liisa Hartikainen, Polasek, Ozren, Kumari, M., Nish Chaturvedi, Lynne E. Wagenknecht, Polak, J., Louise V. Wain, Tzoulaki, I., Jing Hua Zhao, Soininen, P., Penman, A. D., Sehmi, J.S., Anna Köttgen, Mosley, Thomas H., Luan, J., Cristiano Fava, Rotter, J.I., Steven C. Hunt, Psaty, B. M., Alanna C. Morrison, Ehret, Georg B, Gavin Lucas, Debbie A. Lawlor, Hoffman Bolton, Judith A, Heckbert, S. R., Umemura, Satoshi, Mosley, T.H., Wild, Sarah H, Jackson, Anne U, Townsend, RR, Raitakari, Olli, JinGo, Min, Rudan, I., Snieder, Harold, Stephan J.L. Bakker, Thomas J. Wang, Annika Rosengren, Stancakova, A., Fabsitz, R. R., Connell, John M, Kangas, A.J., Eyheramendy, Susana, Tim D. Spector, Palmas, W, Dag S. Thelle, Megan E. Rudock, Van Gilst, W. H., Stancáková, Alena, Thor Aspelund, Shaw-hawkins, S., Ehret, G. B., Hernandez, Dena, Shrine, N.R., Ramachandran, Vasan S, Oostra, Ben A, Andrew Taylor, Kivimaki, M., Chen, M.H., Hyung-Lae Kim, Keating, B. J., Kooner, J. S., Zhao, J. H., Yajnik, C. S., Volzke, H., Wilmar Igl, Dominiczak, A. F., Laakso, Markku, Peden, J. F., Ewa Zukowska-Szczechowska, Jaspal S. Kooner, Polak, JF, Smita R. Kulkarni, Thomas Meitinger, Coresh, J., Hadley, David, Zhu, Haidong, Kardia, S. L. R., Elliott, P., O'Connell, Jeffrey R, Laitinen, J., Veldre, G., Palmer, L. J., Nanette I. Steinle, Casas, J.P., Palmas, W., Hilton, Gina, Helen N. Lyon, Swift, A. J., Bornstein, Stefan R, Altshuler, David, Matthias Olden, Chen, M.-h., Rotimi, C. N., Doumatey, AP, Newton-cheh, C., Francis S. Collins, Hwang, Shih-Jen, Uiterwaal, C.S., Luan, Jian'an, Chandak, G. R., Launer, Lenore, Salako, Tunde, Panos Deloukas, Stringham, Heather M, Najaf Amin, Farlow, DN, Beilby, John P, Vinay, D. G., Smith, N.L., Jennifer L. Bragg-Gresham, Elosua, Roberto, Caulfield, Mark J., Dries, D. L., Tuomilehto, J., Swift, Amy J, Uiterwaal, C. S. P. M., Taylor, Herman A, Munroe, Patricia B, Serge Hercberg, Morrison, Alanna C, Fadi J. Charchar, Arfan Ikram, M., Germaine C. Verwoert, Bok-Ghee Han, Sharon B. Wyatt, Soininen, Pasi, Kardia, Sharon L R, Carl D. Langefeld, Andrew A. Hicks, Farlow, D., Bis, Joshua C, Kang, Sun J., Roberto Elosua, Andre G. Uitterlinden, Curb, J. David, Ehret, G.B., Albert W. Dreisbach, Prabhakaran, D., Salomaa, V., Parsa, Afshin, Dreisbach, AW, Dries, DL, Mohlke, K.L., Campbell, Harry, Platou, C. G. P., Kinra, S., Nguyen, K.-d. H., Hirschorn, J.N., Kivimaki, Mika, Narisu, Narisu, Hingorani, A.D., Afshin Parsa, Johnson, A.D., Fabsitz, R.R., Vollenweider, P., Rasheed, Asif, Linda S. Adair, Voight, Benjamin F, Kardia, SLR, Scott, J., Cho, Y. S., Guo, X., Newton-Cheh, Christopher, Mcardle, W. L., Kuh, Diana, Leena Peltonen, Arking, D.E., McKenzie, C.A., Bochud, M., Wain, L. V., Dries, D., Plump, A., Kulkarni, Smita R, Nilsson, Peter, Meitinger, T., Doumatey, Ayo P, Ozren Polasek, Dreisbach, A., Jeanette Erdmann, Mario A. Morken, Parsa, A., Takayoshi Ohkubo, Kardia, Sharon L.R., Han, Bok-Ghee, Shrine, N. R. G., Albert V. Smith, Smith, A.V., Gonçalo R. Abecasis, Yajnik, C.S., Rosengren, A., Inga Prokopenko, David P. Strachan, Nora Franceschini, Wareham, Nicholas J, Young, J.H., Stringham, H. M., Adeyemo, A, Barroso, I., Smith, G.D., Jan A. Staessen, Kita, Y., Franceschini, N., Nalls, M. A., Vilmundur Gudnason, Tetsuro Miki, Smith, G. D., Lohman, K.K., Guangju Zhai, Young, J Hunter, Mattace-Raso, Francesco U S, Tom R. Gaunt, Alexander, Myriam, Zhu, X, Hingorani, A. D., Langefeld, C.D., Ramachandran, V.S., Lyytikäinen, Leo-Pekka, Wang, Thomas J, Doumatey, Ayo P., Bis, J.C., Wilson, J.F., Okamura, Tomonori, Myriam Alexander, Gerjan Navis, Mattace-raso, F. U. S., Raitakari, O., Rudock, Megan E, International Consortium for Blood Pressure Genome-Wide Association Studies, Connell, J. M., Feng Zhang, Adair, L. S., Beckmann, J. S., Lyytikäinen, L.P., Wong, Tien Y, Gina Hilton, E. Shyong Tai, Scott, Laura J, Peltonen, Leena, Lohman, K. K., Soranzo, N., John F. Peden, Dominiczak, A.F., Charchar, F. J., Tayo, B.O., Dreisbach, Albert W., Lawlor, D.A., Rotter, J. I., Kahonen, M., Boehnke, Michael, Ian N.M. Day, Palmas, Walter, Campbell, H., Eaton, CB, Coresh, Josef, Scott, James, Barbara Ludwig, Heather M. Stringham, Isaacs, A., O'reilly, P. F., Bergman, R. N., CARDIoGRAM consortium, [Unknown], Zitting, Paavo, Hwang, S.J., Levy, D, Wilson, James F; id_orcid, Corsi, Anna Maria, Shuldiner, A. R., O'Reilly, P.F., Lawrence, R. W., Bergmann, S., Pattaro, C., Khaw, K.-t., Stefan R. Bornstein, Collins, R., Frayling, Timothy M, Farrall, M., Teumer, Alexander, Umemura, S., Matullo, G., Martin, Lisa W, Pattaro, Cristian, Leo-Pekka Lyytikäinen, Li, Y, Ehret, Georg B., Nicole L. Glazer, Aroon D. Hingorani, Abecasis, Gonçalo R, Emilsson, Valur, Gaunt, T. R., Tomonori Okamura, Heckbert, S.R., Ming-Huei Chen, Ramachandran, V. S., Gang Shi, Wendy L. McArdle, Collins, F. S., Jutta Palmen, Nilesh J. Samani, Lakatta, Edward G, Veikko Salomaa, Townsend, R. R., Fava, C., Wang, T.J., Lawlor, D. A., Morrison, A., Chambers, J.C., Khaw, Kay-Tee, Yurii Aulchenko, Wu, Ying, Wain, L.V., Chandak, Giriraj R, Muhammad Islam, Viigimaa, M., Day, I.N., Raffel, Leslie J, Kristian Hveem, Taylor, A., Liu, Yongmei, Gerald R. Fowkes, Musani, Solomon K, Soler Artigas, Maria, Samani, Nilesh J, Sekar Kathiresan, Kardia, S.L., Musani, Solomon K., Alan B. Weder, Hirschhorn, J.N., McArdle, W.L., Vollenweider, Peter, Melander, O., Meneton, P., Cooper, J.A., Wong, T.Y., Morrison, AC, Soranzo, Nicole, Hayward, Caroline, Palmer, N. D., Albert Hofman, Ohkubo, T., O'Donnell, Chris, Zelenika, Diana, Voight, B.F., Redline, Susan, Yali Li, Igl, Wilmar, Wild, S. H., Kottgen, A., Morris J. Brown, Farlow, D.N., Iwai, Naoharu, Würz, Peter, Gieger, Christian, Yao, Jie, Kroemer, H.K., Ala-Korpela, Mika, Rotimi, C.N., Viikari, Jorma, Penman, Alan D, Caulfield, MJ, Sim, X., Simonetta Guarrera, Bonnycastle, L.L., Bakker, S. J. L., Mosley, T. H., Kranthi Kumar, M. J., Lyle J. Palmer, M.J. Kranthi Kumar, Fox, E.R., Liu, Kiang, Chakravarti, Aravinda, Fredrik Nyberg, Schwartz, S.M., John M. Connell, Kuusisto, Johanna, Wagenknecht, L.E., Morken, M.A., Adeyemo, A., Alexander Teumer, Alan R. Shuldiner, Grobbee, D. E., Morris, Richard W, Lakatta, E.G., Amin, N., Nyberg, Fredrik, Dreisbach, A.W., Oostra, B.A., Mika Kivimaki, Watkins, Hugh, Morrison, A.C., Harris, T. B., Meschia, J. F., Christian Gieger, Sijbrands, E. J. G., Bergman, Richard N, J. David Curb, Polak, Josef F., Thelle, Dag S, Morken, Mario A, Ioanna Tzoulaki, Raymond R. Townsend, Jafar, T.H., Aspelund, Thor, Polak, J.F., Michael Boehnke, Redline, S., Jackson, A. U., Viigimaa, Margus, Saleheen, Danish, Kim, H.-l., Hardy, Rebecca, Spector, T.D., Sijbrands, E.J., Forrester, T., Navis, Gerjan, Howard, P., Isaacs, Aaron, Verwoert, G.C., Rice, Kenneth M, Kathiresan, Sekar, Larson, Martin G, Tomaszewski, M., Hingorani, Aroon D, Lakatta, E. G., Markus Perola, Loos, R.J., Gyllensten, U.B., Alena Stančáková, Perola, M., Peter Nilsson, Jemma C. Hopewell, Alan D. Penman, Ruth J.F. Loos, Staessen, J. A., Ala-korpela, M., Haidong Zhu, Fabsitz, Richard R, Francesco U.S. Mattace-Raso, Musani, S.K., Abecasis, G. R., Tien Y. Wong, Aulchenko, Yurii, Robert Clarke, Maria SolerArtigas, Jafar, Tazeen H, Arora, P., Chasman, D.I., Janipalli, C. S., Karen L. Mohlke, Kangas, Antti J, Dabeeru C. Rao, Hwang, S.-j., Adair, Linda S, N. Charlotte Onland-Moret, Richard S. Cooper, Anne U. Jackson, Kulkarni, S.R., Gaunt, Tom R, Kutlar, A., Sõber, Siim, Lee, N.R., Leif Groop, Wain, Louise V, Yan V. Sun, Hopewell, J.C., Prabhakaran, Dorairajan, Palmen, J., Staessen, Jan A, Bragg-gresham, J. L., Lucas, G., Terho Lehtimäki, Nanette R. Lee, Fowkes, G. R., Tuomilehto, Jaakko, Paolo Vineis, Solerartigas, M., Richard W. Morris, Kumari, Meena, Eric J.G. Sijbrands, Eaton, C.B., Asif Rasheed, Vartiainen, E., Uda, M., Kroemer, Heyo K, Susan R. Heckbert, Connell, J.M., Ehret, GB, Eaton, Charles B., Morken, M. A., Harris, Tamara B, Kathiresan, S., O'Reilly, Paul F, Amin, Najaf, Kettunen, Johannes, Ganesh, S., Chang, Y.-p. C., H.-Erich Wichmann, Langefeld, Carl D, Elliott, Paul, Zhai, G., Siim Sõber, Dorr, M., Shi, Gang, Shrine, Nick R G, Zhu, H., Kenneth M. Rice, Humphries, S.E., Kardia, SL, Laan, Maris, J. Hunter Young, Bots, M. L., Pankaj Sharma, Vikal Tripathy, Cooper, Matthew N, Samani, N., Peter Vollenweider, Hicks, A. A., Terzic, J., Ganesh, S, Yoon Shin Cho, Ben A. Oostra, Swift, A.J., Eaton, Charles B, Schwarz, P. E. H., Manuela Uda, Matullo, Giuseppe, Sehmi, J. S., Palmer, Nicholette D, Demirkan, A., Bochud, Murielle, Weder, A.B., Boerwinkle, Eric, Humphries, Steve E, Jacqueline C.M. Witteman, Beilby, J.P., Wyatt, Sharon B, Wichmann, H.E., Martin Farrall, Hveem, K., Martin D. Tobin, Paul R. Burton, Mooser, Vincent, Mohlke, K. L., Curb, J David, Cooper, M.N., Heckbert, Susan R, Eyheramendy, S., Bandinelli, S., Taylor, HA, Orru, M., Tayo, BO, Hunt, S. C., Ervin R. Fox, Aspelund, T., Liu, K, Morrison, A. C., Levy, Daniel, Tamara B. Harris, oel, Anuj, Wichmann, H-Erich, Cooper, RS, Bonnycastle, L. L., Wong, A., Taylor, H. A., Xueling Sim, Watkins, H., Charchar, F.J., Nicholette D. Palmer, Wagenknecht, L. E., Wright, Alan F, Diederick E. Grobbee, ICBP Consortium (Meitinger, T. ; Wichmann, H.-E.), Vineis, Paolo, Brown, M.J., Narisu, N., Mark J. Caulfield, Yuri Milaneschi, Ueshima, Hirotsugu, Jerome I. Rotter, Lee, J.Y., Danesh, J., Bots, Michiel L, Sanjay Kinra, Paul M. Ridker, Campbell, Harry; id_orcid, Wiggins, K.L., Kuznetsova, Tatiana, Chandak, G.R., Chasman, Daniel I, Johnson, A. D., Peter S. Braund, Singleton, Andrew, Lehtimaki, T., Ridker, P. M., Johnson, T., Tazeen H. Jafar, ?, ?, Zhao, Jing Hua, Kao, W. H. L., O'donnell, C., Kao, Wen Hong Linda, Witteman, Jacqueline C M, Townsend, Raymond R., Martin G. Larson, Shuldiner, A.R., Rudock, M.E., Rotimi, Charles N, Mark Lathrop, Arking, Dan E, Musani, SK, Musani, S., Seshadri, S., Platou, C.G., Tzoulaki, Ioanna, Hilton, G., Fowkes, F Gerald R, Mark Seielstad, Caulfield, M. J., Wiggins, Kerri L, Uda, Manuela, John P. Beilby, Ying Wu, Guo, Xiuqing, Bandinelli, Stefania, Bakker, S.J., Prokopenko, Inga, International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Fulvio Ricceri, Dena Hernandez, Narisu Narisu, Ikram, M Arfan, Bergmann, Sven, Daniel I. Chasman, Rasheed, A., Tobin, M.D., Richard R. Fabsitz, Adair, L.S., Martin, LW, Scuteri, A., Palmen, Jutta, Adebowale Adeyemo, Abecasis, G.R., Sun J. Kang, Rao, Dabeeru C, Dreisbach, Albert W, Chittaranjan S. Yajnik, Peter Würz, Rotimi, CN, Taru Tukiainen, Ueshima, H., Wurz, P., Rotter, Jerome I, Chen, Ming-Huei, Alan F. Wright, Kang, S. J., Kuh, D., Franceschini, Nora, Andrew Wong, Goel, A., Stringham, H.M., Lyon, H. N., Marco Orru, Janipalli, C., Vincent Mooser, Curb, J. D., Fox, E., Kardia, Sharon LR, Andrew Singleton, Curb, J.D., Laakso, M., Hunt, Steven C, Dörr, Marcus, Juan P. Casas, Terzic, Janos, Erdmann, J., Arora, Pankaj, Murielle Bochud, Vasyl Pihur, Kuusisto, J., van Duijn, C.M., Philippa J. Talmud, Wagenknecht, Lynne E, Levy, D., Chambers, J. C., Parker, Alex N, Sjögren, Marketa, Simon Heath, Paavo Zitting, Fowkes, F.G., Raffel, L.J., Hirschorn, Joel N., Anders Hamsten, Bornstein, S.R., Adeyemo, Adebowale, van der Harst, Pim, Loos, R. J. F., Jafar, T. H., Sun, Yan V, Luigi Ferrucci, Ludwig, B., Corsi, A.M., Schwarz, P.E., Kähönen, Mika, Tobin, Martin D, Anuj Goel, Paul Elliott, Sun, Yan V., Mika Kähönen, Witteman, J. C. M., Jie Yao, Uitterlinden, A. G., Stefan-Martin Brand, Deloukas, P., Wang, T. J., Fox, ER, Weder, Alan B, Frayling, T. M., Dehghan, A., CKDGen consortium, [Unknown], Guarrera, Simonetta, Teumer, A., Pim van der Harst, Joban S. Sehmi, James Scott, Andrew Plump, Wareham, N. J., Sjogren, M., Beckmann, J.S., Bragg-Gresham, J.L., Kao, W.H., Kinra, Sanjay, Shuldiner, Alan R, Plump, Andrew, Daniel Levy, Polasek, O., Lohman, Kurt K, Hirschorn, J. N., Wyatt, S.B., International Consortium for Blood Pressure Genome-wide Associat, Munroe, P.B., Kita, Yoshikuni, Amy J. Swift, Kutlar, Abdullah, Wild, Sarah H; id_orcid, Jackie A. Cooper, Taylor, Andrew, Grobbee, Diederick E, Nalls, Michael A, Seielstad, M., Ayo P. Doumatey, Wu, Y., Zhang, Feng, Glazer, N. L., David Altshuler, Marmot, Michael G, Deloukas, Panos, Rosengren, Annika, Twee-hee Ong, R., Ohkubo, Takayoshi, Margus Viigimaa, O'Connell, J.R., Steinle, Nanette I, Laura J. Scott, Saleheen, D., Laitinen, Jaana, Rory Collins, Jarvelin, M.-r., Burton, P. R., Go, Min Jin, Collins, Rory, Talmud, P. J., Kim, H.L., Hofman, Albert, Zhao, J.H., Yongmei Liu +999 morecore +1 more sourceCell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceReciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment
, 2009 Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin +10 morecore +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more source
