Results 101 to 110 of about 10,254,786 (382)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
FluidsThe development of optical noninvasive methods for assessing the functional state of peripheral vessels, including the microcirculatory vascular bed, requires advances in modeling peripheral hemodynamics in order to interpret diagnostic data in terms of ...
Andrey P. Tarasov +2 more
doaj +1 more source
Frontiers in Pediatrics, 2018 Introduction: Conflicting data have been published on the reduction of circulating blood volume in adults with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The aim of the present study was to compare blood volumes based on the presence or
C. (Linda) M. C. van Campen +2 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Development and Cell Biology of the Blood-Brain Barrier.
Annual Review of Cell and Developmental Biology, 2019 The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue.
Urs H. Langen, S. Ayloo, Chenghua Gu
semanticscholar +1 more source
Transcutaneous measurement of volume blood flow [PDF]
Blood flow velocity measurements, using Doppler velocimeter, are described. The ability to measure blood velocity using ultrasound is derived from the Doppler effect; the change in frequency which occurs when sound is reflected or transmitted from a ...
Daigle, R. E. +4 more
core +1 more source
Validation of the Medonic CA620/530 Vet 20-ml microcapillary sampler system for hematology testing of feline blood [PDF]
, 2009 The aim of the current study was to compare feline hematologic variables in blood collected in microcapillary tubes (20 ml) and conventional blood tubes with the Medonic CA620/530 Vet in-house hematologic analyzer.
Bourges-Abella, Nathalie +4 more
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Experimental PhysiologyDuring pregnancy an increased cardiac output (Q̇) and blood volume (BV) occur to support fetal growth. Increased Q̇ and BV also occur during chronic endurance exercise training and benefit performance.
Normand Richard +3 more
doaj +1 more source
Elevated central venous pressure: A consequence of exercise training-induced hypervolemia [PDF]
Resting plasma volumes, and arterial and central venous pressures (CVP) were measured in 16 men before and after exercise training to determine if training-induced hypervolemia could be explained by a change in total vascular capacitance.
Convertino, Victor A. +2 more
core +1 more source