Results 81 to 90 of about 11,775,341 (296)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A guideline for transfusion of red blood cells in surgical patients

, 2000
Blood transfusion carries a real but unquantifiable risk of adverse outcome in surgical patients from infectious, immunological and cardiorespiratory morbid events.
National Blood Users Group
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Effect of Propranolol in Human Body Using Gold Nanoparticles by Spectrofluorometric Method

Bihdād, 2018
In this method, gold nanoparticles have been synthesized by reducing the gold salt and the Spectrofluorometric spectrum is taken from it. Determination of  propranolol is widely used in the treatment of blood pressure and irregular heart beat .The ...
Ali Akbar Shadbahr, Farzaneh Marahel
doaj  

Determination and analysis of reference interval of leukocyte-depleted suspended red blood cell volume in Xi′an

Zhongguo shuxue zazhi
Objective To establish the internal quality control standard of leukocyte-depleted suspended red blood cell volume in our center, so as to guide the preparation of components, strengthen the internal quality control and improve the quality of blood ...
Xin CAO, Nana PING, Jin DING, Peng PENG, Na LIU, Yutong ZHANG, Na FENG   +6 more
doaj   +1 more source

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD [PDF]

, 2011
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the ...
Smith, Antony, Ian R. MacGregor, Groschup, Martin H., Hunter, N., Hunter, Nora, Prowse, C.V., Tan, B.C., Hornsey, V.S., Boon Chin Tan, Sandra McCutcheon, Jean C Manson, Antony Smith, E. Fiona Houston, Jean C. Manson, Alejo-Blanco, Richard, Manson, J.C., Tan, Boon Chin, Turner Marc, Manson, Jean C., Houston E. Fiona, Alejo Blanco, A.R., Turner, Marc, Groschup Martin H., MacGregor, Ian R., Houston, Fiona, Christopher V Prowse, Turner, M., E Fiona Houston, Alejo Blanco Anthony Richard, Groschup, M.H., Martin H Groschup, Smith Antony, de Wolf, C., Christopher V. Prowse, Hunter Nora, Prowse, Christopher V., Christopher de Wolf, Anthony Richard Alejo Blanco, MacGregor Ian R., de Wolf Christopher, Marc Turner, de Wolf, Christopher, Valerie S. Hornsey, Smith, A., Manson Jean C., Prowse Christopher V., Ian R MacGregor, Prowse, C. V., Hornsey, Valerie S., McCutcheon Sandra, MacGregor, I.R., McCutcheon, Sandra, Nora Hunter, Tan Boon Chin, Hornsey Valerie S., Martin H. Groschup, McCutcheon, S., Houston, E.F., Valerie S Hornsey   +58 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

ENURESIS IN ADOLESCENTS AND CONSCRIPTS: MODERN APPROACHES TO DIAGNOSTICS

Педиатрическая фармакология, 2014
The article lists results of a complex examination of adolescents and conscripts of 15–23 years of age with enuresis performed according to the Ulyanovsk Region military commissariat’s referral in 2003–2012.
A. L. Malykh, I. N. Zakharova, M. I. Pykov   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source