Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu+14 more
wiley +1 more source
Correction: Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2. [PDF]
Luo Y+8 more
europepmc +1 more source
Loss of NR2F6 Protects from Salmonella Typhimurium Infection
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk+8 more
wiley +1 more source
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin. [PDF]
Liao X+15 more
europepmc +1 more source
GRIN2B alleviates mid-gestational sevoflurane exposure-induced early differentiation of rat neural stem cells by interacting with KIF17. [PDF]
Li M, Hu Y, Cheng Z, Li Q.
europepmc +1 more source
Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation. [PDF]
Dai J+8 more
europepmc +1 more source
PI31 is a positive regulator of 20S immunoproteasome assembly.
Wang J, Kjellgren A, DeMartino GN.
europepmc +1 more source
Anti-inflammatory and barrier repair mechanisms of active components in Daemonorops draco Bl. for UVB-induced skin damage. [PDF]
Wu X+7 more
europepmc +1 more source
Corrigendum: LINC-PINT suppresses cisplatin resistance in gastric cancer by inhibiting autophagy activation <i>via</i> epigenetic silencing of ATG5 by EZH2. [PDF]
Zhang C+9 more
europepmc +1 more source