Results 41 to 50 of about 14,282 (244)

Genetics of melanoma progression: the rise and fall of cell senescence. [PDF]

, 2016
There are many links between cell senescence and the genetics of melanoma, meaning both familial susceptibility and somatic-genetic changes in sporadic melanoma.
Al-Khalaf, Albino, Alimonti, Alonso, Anders, Aoude, Aoude, Artandi, Bandyopadhyay, Bandyopadhyay, Barrett, Bartkova, Bastian, Bastian, Bataille, Bell, Ben-Porath, Bennett, Bennett, Bennett, Berger, Bevona, Bond, Boyle, Cairney, Campisi, Cao, Carvajal, Carvalho, Chandler, Chen, Chien, Christensen, Chudnovsky, Clark, Conde-Perez, Coppé, Coppé, Corre, Curtin, Curtin, Cust, Dankort, Delmas, DePinho, Dhomen, Ding, Dono, Easty, Forbes, Freund, Fujimoto, Fung, Garrido, Gembarska, Gisselsson, Glaessl, Goldstein, Gray-Schopfer, Griewank, Gruis, Ha, Ha, Hanahan, Hayflick, Heaphy, Helgadottir, Herbig, Herbig, Hewitt, Hodis, Hoek, Horn, Huang, Hurk, Hussussian, Iles, Jacobs, Jacobs, Jeck, Johmura, Jönsson, Kraehn, Krauthammer, Krauthammer, Kuilman, Kuilman, Lade-Keller, Lam, Laoukili, Lawrence, Lin, Lin, Londono-Vallejo, MacKenzie Ross, Martínez, Michaloglou, Mooi, Moore, Muñoz-Espín, Nagel, Nan, Narita, Newton-Bishop, Nogueira, Ogbah, Ohanna, Overhoff, Passos, Patton, Pavey, Pawlikowski, Petti, Poliakov, Pollock, Prickett, Reddel, Ressler, Rhee, Robert, Robles-Espinoza, Rode, Rossiello, Rovillain, Ruas, Ruhe, Salama, Sargen, Sato, Serrano, Shay, Shi, Shitara, Snoo, Soengas, Soo, Stark, Stefanaki, Stratton, Straume, Suram, Sviderskaya, Sviderskaya, Sviderskaya, The Cancer Genome Atlas Network, Topping, Tran, Treszl, Tsao, Von Zglinicki, Vredeveld, Wansleben, Wellbrock, Wen, Widmer, Worm, Xia, Xiong, Zhang, Zhu   +159 more
core   +1 more source

The importance of p16 and CD117 expression in melanocytic lesions

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2021
Aim: The present study aims to determine the p16 and CD117 expression profiles of melanocytic lesions to investigate immune profiles that may facilitate differential diagnosis of melanoma from benign or potential precursor melanocytic lesions.Materials ...
Sevil Karabağ, Ayşegül İsal Arslan
doaj   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Diagnosis of oral pigmentations and malignant transformations [PDF]

, 1951
BackgroundOral pigmentation is a common finding in the mouth. Pigmentation can be either normal or abnormal discoloration of oral mucous membrane.
Eisen, Kleinegger, Gaeta, Hemminki, Hemminki, Hemminki, McGrath, Kauzman, Dereure, Birek, Kim, Weathers, Buchner, Gupta, Zaraa, Esen, Halder, Hedin, Hedin, Axell, Araki, Perusse, Marks, McAllan, Savage, Westbury, Meyerson, Buchner, Hicks, Goode, Whitt, Barker, Gorsky   +32 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

An Unusual Melanocytic Nevus of Conjunctiva : Balloon Cell Nevus [PDF]

, 2011
Melanocytic nevi are one of the most common benign tumors of the conjunctiva. The balloon cell nevus is a rare and unusual variant of nevus of melanocytic origin, in which more than 50% of the tumor is composed of large polygonal cells with small nucleus
Geethalakshmi, U, Nischal, KC, Padmini, HR, Vijay Shankar, S   +3 more
core  

Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma

, 2014
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view.
Alemi, Alexander A., Ciusani, Emilio, La Porta, Caterina A. M., Sethna, James P., Taloni, Alessandro, Zapperi, Stefano   +5 more
core   +3 more sources

Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study [PDF]

, 2014
IMPORTANCE: The clinical phenotype and certain predisposing genetic mutations that confer increased melanoma risk are established; however, no consensus exists regarding optimal screening for such individuals.
Coates, Elliot, Guitera, Pascale, Haass, Nikolas K., Ho, Kenneth, Khoury, Ritta, Mann, Graham J., Menzies, Scott W., Moloney, Fergal J., O'Connell, Rachel L., Raudonikis, Leo, Schmid, Helen   +10 more
core   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Epithelioid Cell Histiocytoma – An Unusual Variant of Dermatofibroma at an Uncommon Site [PDF]

, 2011
Epithelioid cell histiocytoma (ECH) is a rare variant of cutaneous fibrous histiocytoma involving primarily trunk and the extremities. It can delude the pathologist in considering other benign non neoplastic and neoplastic lesions.
K, Amita, KC, Nischal, VS, Shulbha
core   +1 more source