Results 51 to 60 of about 12,984 (208)

Diagnosis of oral pigmentations and malignant transformations [PDF]

, 1951
BackgroundOral pigmentation is a common finding in the mouth. Pigmentation can be either normal or abnormal discoloration of oral mucous membrane.
Eisen, Kleinegger, Gaeta, Hemminki, Hemminki, Hemminki, McGrath, Kauzman, Dereure, Birek, Kim, Weathers, Buchner, Gupta, Zaraa, Esen, Halder, Hedin, Hedin, Axell, Araki, Perusse, Marks, McAllan, Savage, Westbury, Meyerson, Buchner, Hicks, Goode, Whitt, Barker, Gorsky   +32 more
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study [PDF]

, 2014
IMPORTANCE: The clinical phenotype and certain predisposing genetic mutations that confer increased melanoma risk are established; however, no consensus exists regarding optimal screening for such individuals.
Coates, Elliot, Guitera, Pascale, Haass, Nikolas K., Ho, Kenneth, Khoury, Ritta, Mann, Graham J., Menzies, Scott W., Moloney, Fergal J., O'Connell, Rachel L., Raudonikis, Leo, Schmid, Helen   +10 more
core   +1 more source

Phenotype Expansion of Malan Syndrome: New Cases and a Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Malan syndrome is an ultra‐rare overgrowth syndrome caused by pathogenic variants or deletions in nuclear factor one X (NFIX) located at 19p13.2. Here, we report a comprehensive literature review and phenotyping of known patients with Malan syndrome and present a novel cohort of eight patients.
Alex F. Nisbet, Sylvie A. Adams, Zoe S. Katz, Christal G. Delagrammatikas, Kosuke Izumi, Winifred Sigal, Kim Ventarola, Elaine H. Zackai, Julia E. Reid, Grant T. Liu, Jennifer M. Kalish   +10 more
wiley   +1 more source

Clinical and pathological characteristics of childhood blue nevus

Pifu-xingbing zhenliaoxue zazhi
[Objective] To summarize the clinical, dermatoscopic and pathological features of blue nevus in children. [Methods] Clinical data, dermatoscopic images, and pathological reports were collected from 104 children with blue nevus at the dermatology ...
YANG Xueqi, YANG Xinyu, CHEN Qian, ZHU Lei, QIAN Hua   +4 more
doaj   +1 more source

The management of ophthalmic involvement in blue rubber bleb nevus syndrome

GMS Ophthalmology Cases, 2014
[english] Objective: Blue rubber bleb nevus syndrome is a rare vascular disease most commonly associated with venous malformations of the skin and the gastrointestinal tract. Few ophthalmic cases have been reported to date, and no clear treatment regimen
Petek, Bradley, Jones, Robin L.
doaj   +1 more source

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi [PDF]

, 2016
Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system.
BERARDI, Alberto, CIARDO, Silvana, FARNETANI, Francesca, MANDEL, Victor Desmond, PELLACANI, Giovanni, PERSECHINO, Flavia, PONTI, Giovanni, ROSSI, Cecilia   +7 more
core   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, EarlyView.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

Sinonasal blue nevus: a case report and review

Ear, Nose & Throat Journal
Blue nevus is a type of uncommon benign pigmented lesion in the skin or the mucosa of human body which is featured by pigmented dendritic melanocytes and spindled melanocytic cells. Sinonasal blue nevus is extremely rare.
Rui Lu MD, Wei Xiao MD, PhD, Xiong Chen MD, PhD, Zhiyong Li MD, PhD   +3 more
doaj   +1 more source

A rare case of blue nevus in the rectum

Human Pathology: Case Reports, 2019
A 54 year old female of Sudanese origin with a history of hypothyroidism and hyperlipidemia presented to the gastroenterology department complaining of chronic abdominal pain, nausea and heartburn. Colonoscopy revealed an incidental 5 mm pigmented lesion
Shroque Zaher, Nada Sedeeq
doaj   +1 more source