Results 41 to 50 of about 12,984 (208)

Phakomatosis Pigmentovascularis [PDF]

, 1996
We report a patient with phakomatosis pigmentovascularis IIb and numerous iris hamartomas. Phakomatosis pigmentovascularis IIb is characterized by the simultaneous occurrence of a nevus flammeus, a mongolian spot, and sometimes a nevus anemicus in the ...
Gysel, D. (Dirk) van, Oranje, A.P. (Arnold), Simonsz, H.J. (Huib), Stroink, H. (Hans)   +3 more
core   +6 more sources

Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma

, 2014
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view.
Alemi, Alexander A., Ciusani, Emilio, La Porta, Caterina A. M., Sethna, James P., Taloni, Alessandro, Zapperi, Stefano   +5 more
core   +3 more sources

Onychoscopy [PDF]

, 2013
Dermatoscopy can be used to evaluate the nail apparatus (ie, onychoscopy), and it is helpful for the diagnosis of numerous nail diseases and tumors. This article reviews the information that can be obtained in cases of nail dyschromia and especially in ...
Lamas, A, Lencastre, A, Sá, D, Tosti, A
core   +1 more source

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. [PDF]

, 2018
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown,
A Dagklis, A Dagklis, A El Andaloussi, A Gutierrez, A Sekulic, AA Ferrando, AE Place, AK Fielding, AL Furmanski, AM Kenney, C Reynolds, CH Pui, CJ Neumann, DD Hoff Von, DI Marks, DM Stone, DV Catenacci, E Drakopoulou, E Lindstrom, GW Robinson, H Hahn, H Hahn, HA Zahreddine, HJ Sharpe, I Hofmann, J Briscoe, J Chen, J Gao, J Rodon, J Taipale, JM Goldberg, JS Blackburn, JY Tang, KD Robarge, LV Goodrich, M Aszterbaum, M Duman-Scheel, M Sadelain, M Schrappe, MJ Koudijs, NJ Rowbotham, PD Bhola, PD Stenson, PL So, PM LoRusso, RH Ko, RL Johnson, S Hettmer, SB Kaye, SP Hunger, SS Winter, SV Outram, T Ni Chonghaile, TT Vo, Y Liu   +54 more
core   +1 more source

The importance of p16 and CD117 expression in melanocytic lesions

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2021
Aim: The present study aims to determine the p16 and CD117 expression profiles of melanocytic lesions to investigate immune profiles that may facilitate differential diagnosis of melanoma from benign or potential precursor melanocytic lesions.Materials ...
Sevil Karabağ, Ayşegül İsal Arslan
doaj   +1 more source

Cutis verticis gyrata in a patient with multiple basal cell carcinomas; case presentation and review of the literature [PDF]

, 2016
Cutis verticis gyrata is a rare disease characterized by convoluted folds and deep furrows of the scalp, resembling the gyri and sulci of the cerebral cortex.
Benea, Vasile, Georgescu, Simona Roxana, Mitran, Cristina Iulia, Mitran, Mădălina Irina, Rusu, Alice, Sârbu, Maria Isabela, Tampa, Mircea   +6 more
core   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Epithelioid Cell Histiocytoma – An Unusual Variant of Dermatofibroma at an Uncommon Site [PDF]

, 2011
Epithelioid cell histiocytoma (ECH) is a rare variant of cutaneous fibrous histiocytoma involving primarily trunk and the extremities. It can delude the pathologist in considering other benign non neoplastic and neoplastic lesions.
K, Amita, KC, Nischal, VS, Shulbha
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source