Results 111 to 120 of about 54,565 (260)

P712: Genetic findings in over 500 individuals tested with a spastic paraplegia gene panel

Genetics in Medicine Open
Allison Sluyters, Kirsi Alakurtti, Mònica Segura Castell, Äsa Hagström, Heli Kuisma, Eija Seppälä, Kimberly Gall, Julie Hathaway, Alicia Scocchia, Mikko Muona, Inka Saarinen, Lotta Koskinen, Pertteli Salmenperä, Samuel Myllykangas, Juha Koskenvuo   +14 more
doaj   +1 more source

Shared spatial and temporal principles govern connectome dynamics across timescales. [PDF]

Proc Natl Acad Sci U S A
Alderson TH, Jun S, Wirsich J, Egan MK, ElSayed SW, Giakas SA, Mostame P, Harper J, Giraud AL, Malone SM, Iacono WG, Koyejo S, Sadaghiani S.   +12 more
europepmc   +1 more source

Gel Electrolytes for Flexible Zinc‐Air Batteries: Design, Challenges, and Perspectives

Advanced Science, EarlyView.
This review summarizes design strategies for gel electrolytes in flexible zinc‐air batteries, focusing on dendrite suppression, interfacial stability, and ultrathin architectures to enhance cycle life and energy density. ABSTRACT Flexible zinc‐air batteries (FZABs) have emerged as promising candidates for next‐generation flexible electronics and large ...
Yapeng Cao, Tengteng Gu, Yuqiong Wen, Xingxing Gao, Jian Wang, Jun Liu   +5 more
wiley   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Efficacy and safety of avapritinib in advanced systemic mastocytosis: 4-year follow-up of the PATHFINDER study. [PDF]

Blood Adv
Gotlib J, Reiter A, Radia DH, Álvarez-Twose I, Deininger MW, George TI, Panse J, Mital A, Pettit KM, Vannucchi AM, Platzbecker U, Hermine O, Elshoury A, Livideanu CB, Mesa R, Ustun C, Triggiani M, Dybedal I, Jurcic JG, Zanotti R, Oh ST, Yacoub A, Hexner EO, Bose P, Lee SG, Sperr WR, Griffiths EA, Butler M, Lübke J, Bidollari I, Lin HM, Rylova S, Dimitrijević S, Muñoz-González JI, DeAngelo DJ.   +34 more
europepmc   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Preoperative planning software as a digital health tool in orthopedics: Surgeon-reported benefits in shoulder arthroplasty. [PDF]

Surg Open Sci
Reynier M, Shank S, Venegoni M, Regling M, de Gast A.   +4 more
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Identification of racial disparities across MammaPrint and BluePrint subtypes in HR + HER2- breast cancer. [PDF]

NPJ Breast Cancer
Reid S, Venton L, Whisenant JG, Weidner AE, Wei J, Ramaswamy H, Dreezen C, Chmielewski-Stivers N, Menicucci AR, Audeh W, Pal T.   +10 more
europepmc   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source