Results 1 to 10 of about 2,013 (145)

A case of indolent systemic mastocytosis responding to treatment with Avapritinib [PDF]

Clinical Case Reports (discontinued), 2023
Key Clinical Message Low dose Avapritinib is a new medication that is a potential treatment option not just for advanced systemic mastocytosis, but also for the indolent form.

exaly   +5 more sources

Treatment of indolent systemic mastocytosis with sarilumab is not supported in a randomized trial [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems.
Hirsh Komarow, Dean Metcalfe
exaly   +6 more sources

Chronic Anaphylaxis With Indolent Systemic Mastocytosis: A Case Report [PDF]

Case Reports in Hematology
Systemic mastocytosis is a rare, clonal mast cell disease neoplasm driven by the KIT D816V mutation in greater than 95% of cases. The complex clinical presentation of systemic mastocytosis can make diagnosis challenging.
Sarah Worth, Tracy I. George, Daniel J. Shaheen, Maria Roche, Pankit Vachhani   +4 more
doaj   +4 more sources

Efficacy of Omalizumab in Indolent Systemic Mastocytosis [PDF]

Case Reports in Hematology, 2019
Background. Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by the proliferation of clonal mast cells in skin and various internal organs.
Calum Slapnicar, Martina Trinkaus, Lisa Hicks, Peter Vadas   +3 more
doaj   +6 more sources

DNA methylation profile in patients with indolent systemic mastocytosis [PDF]

Clinical and Translational Allergy, 2021
Background Mastocytosis is a clinically heterogeneous, usually acquired disease of the mast cells with a survival time that depends on the onset of the disease and ranges from skin‐limited to systemic disease, including indolent and more aggressive ...
Aleksandra Górska, Ewa Jabłońska, Edyta Reszka, Marek Niedoszytko, Magdalena Lange, Marta Gruchała‐Niedoszytko, Justyna Jarczak, Dominik Strapagiel, Magdalena Górska‐Ponikowska, Paulina Bastian, Iwona Pelikant‐Małecka, Leszek Kalinowski, Bogusław Nedoszytko   +12 more
doaj   +5 more sources

Anaphylaxis events in the PIONEER study of avapritinib in indolent systemic mastocytosis [PDF]

World Allergy Organization Journal
Background: Patients with indolent systemic mastocytosis (ISM), a clonal mast cell disease primarily driven by the KIT D816V mutation, often have lifelong debilitating symptoms.
Thanai Pongdee, MD, Mariana Castells, MD, PhD, Cem Akin, MD, Ingunn Dybedal, MD, PhD, Jason Gotlib, MD, Jens Peter Panse, MD, Ivan Alvarez-Twose, MD, PhD, Cristina Morales Cabeza, MD, Sonia Cerquozzi, MD, FRCPC, Peter Vadas, MD, Vidushi Swarup, MS, Pankit Vachhani, MD, Friederike Wortmann, MD, Cecilia Arana Yi, MD, Ilda Bidollari, MD, Kate Newberry, PhD, Daniel Shaheen, PharmD, Karin Hartmann, MD   +17 more
doaj   +4 more sources

Delayed Diagnosis of Indolent Systemic Mastocytosis as the Cause of Unexplained Skin Rash: A Case Report [PDF]

Case Reports in Oncology, 2023
Mastocytosis is a heterogeneous group of disorders in which mast cells exhibit clonal proliferation that infiltrates one or more organs. In cutaneous mastocytosis, the mast cells infiltrate the skin only, whereas systemic mastocytosis is diagnosed when ...
Awni Alshurafa, Mohammad Abu-Tineh, Feryal A. Ibrahim, Mahir Petkar, Mohamed A. Yassin   +4 more
doaj   +2 more sources

Development of symptom-focused outcome measures for advanced and indolent systemic mastocytosis: the AdvSM-SAF and ISM-SAF© [PDF]

Orphanet Journal of Rare Diseases, 2021
Background Advanced systemic mastocytosis (AdvSM), indolent systemic mastocytosis (ISM), and smoldering systemic mastocytosis (SSM) are rare diseases characterized by neoplastic mast cell infiltration of more than one organ.
Fiona Taylor, Cem Akin, Roger E. Lamoureux, Brad Padilla, Tanya Green, Anthony L. Boral, Iyar Mazar, Brenton Mar, Alan L. Shields, Frank Siebenhaar   +9 more
doaj   +2 more sources

Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF©) and determination of a threshold score for moderate symptoms [PDF]

Orphanet Journal of Rare Diseases, 2023
Background The Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) (©Blueprint Medicines Corporation), a 12-item daily diary that assesses 11 signs and symptoms of indolent systemic mastocytosis (ISM) and smoldering systemic mastocytosis ...
Alan L. Shields, Fiona Taylor, Roger E. Lamoureux, Brad Padilla, Kas Severson, Tanya Green, Anthony L. Boral, Cem Akin, Frank Siebenhaar, Brenton Mar   +9 more
doaj   +2 more sources

Venom immunotherapy in indolent systemic mastocytosis with high serum tryptase level [PDF]

Human Vaccines & Immunotherapeutics, 2021
Mastocytosis is a rare group of disorders characterized by abnormal accumulation of mast cells in the skin, bone marrow, and internal organs. In particular, patients with systemic mastocytosis are at an increased risk of frequent and severe episodes of ...
Ali Selcuk, Abdullah Baysan
doaj   +2 more sources