Results 11 to 20 of about 2,013 (145)

Delayed diagnosis of adult indolent systemic mastocytosis [PDF]

Dermatology Reports, 2014
Systemic mastocytosis (SM) is a rare, heterogeneous disorder characterized by infiltration and accumulation of mast cells within multiple organs, most commonly the skin. Given the rarity of the disease and the fact that many of its symptoms are shared by
Carsten Sauer Mikkelsen, Andrew Nybo, Kristian Bakke Arvesen, Johan Holk-Poulsen   +3 more
doaj   +5 more sources

Diagnosis of indolent systemic mastocytosis in a patient with “seborrheic keratosis” [PDF]

Hematology, Transfusion and Cell Therapy, 2022
Habib Moshref Razavi, Samuel Krikler
doaj   +5 more sources

TREATMENT OF INDOLENT AND ADVANCED SYSTEMIC MASTOCYTOSIS

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Management of Indolent and Smoldering SM is focused on preventing anaphylactic reactions, identifying and avoiding symptom triggers. Skin and gastrointestinal symptoms are managed with H1- and H2-antihistamines.
Alessandro Buonomo, Eleonora Nucera, Marianna Criscuolo   +2 more
doaj   +4 more sources

Psychometric evaluation of the Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) in a phase 2 clinical study [PDF]

Orphanet Journal of Rare Diseases, 2021
Background Indolent systemic mastocytosis (ISM) is a rare, clonal mast cell neoplasm characterized by severe, unpredictable symptoms. The Indolent Systemic Mastocytosis Symptom Assessment Form (ISM-SAF) items compose a Total Symptom Score (TSS ...
Brad Padilla, Alan L. Shields, Fiona Taylor, Xiaoran Li, Jeffrey Mcdonald, Tanya Green, Anthony L. Boral, Hui-Min Lin, Cem Akin, Frank Siebenhaar, Brenton Mar   +10 more
doaj   +2 more sources

Indolent Systemic Mastocytosis: An Incidental Diagnosis

Annals of Internal Medicine: Clinical Cases
Indolent systemic mastocytosis (ISM) is the most prevalent subtype of systemic mastocytosis, characterized by a clinical course progressing over several years to decades.
Ayesha Khalid, Arfa Faiz, Alan Kaell
doaj   +2 more sources

Indolent systemic mastocytosis and aleukemic mast cell leukemia: Subtle diagnostic differences with distinct management approaches [PDF]

JAAD Case Reports, 2023
Elie Saliba
exaly   +2 more sources

The evaluation, management, and future of indolent systemic mastocytosis. [PDF]

Ann Hematol
Indolent systemic mastocytosis (ISM) is a chronic hematologic malignancy that has traditionally been managed primarily by allergists. However, with improved molecular diagnostics such as droplet digital PCR (ddPCR) for KIT D816V on bone marrow aspirate specimens and the availability of targeted therapies against KIT, hematologists are increasingly ...
Syal A, Toh J, McInerney A, Tremblay D.
europepmc   +3 more sources

A Multidisciplinary Diagnostic Approach Reveals a Higher Prevalence of Indolent Systemic Mastocytosis: 15-Years’ Experience of the GISM Network [PDF]

Cancers, 2021
Ilaria Tanasi, Patrizia Bonadonna, Massimiliano Bonifacio   +2 more
exaly   +2 more sources

Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis

Haematologica, 2011
Systemic mastocytosis (SM) is a heterogeneous disorder characterized by the proliferation and accumulation of atypical mast cells (MC) in tissues, principally in the bone marrow (BM) and skin. The diagnosis of systemic mastocytosis requires the presence of multifocal dense mast cell infiltrates ...
Roberta Zanotti, Patrizia Bonadonna, Massimiliano Bonifacio, Anna Artuso, Donatella Schena, Maurizio Rossini, Omar Perbellini, Sabrina Colarossi, Marco Chilosi, Giovanni Pizzolo   +9 more
doaj   +4 more sources

Avapritinib versus Placebo in Indolent Systemic Mastocytosis [PDF]

NEJM Evidence, 2023
BACKGROUND: Indolent systemic mastocytosis (ISM) is a clonal mast-cell disease driven by the KIT D816V mutation. We assessed the efficacy and safety of avapritinib versus placebo, both with best supportive care, in patients with ISM. METHODS: We randomized patients with moderate to severe ISM (total symptom score [TSS] of ≥28; scores range from 0 to ...
van Daele, Paul, Gotlib, Jason, Castells, Mariana, Oude Elberink, J. Hanneke N.G., Siebenhaar, Frank, Hartmann, Karin, Broesby-Olsen, Sigurd, George, Tracy I., Panse, Jens, Alvarez-Twose, I, Radia, Deepti H., Tashi, Tsewang, Livideanu, Cristina Bulai, Sabato, Vito, Heaney, Mark, van Daele, Paul, Cerquozzi, Sonia, Dybedal, Ingunn, Reiter, Andreas, Pongdee, Thanai, Barete, Stephane, Ustun, Celalettin, Schwarts, Lawrence, Ward, Brant R., Schafhausen, Philippe, Vadas, Peter, Bose, Prithviraj, DeAngelo, Daniel J., Rein, Lindsay, Vachhani, Pankit, Triggiani, Massimo, Bonadonna, Patrizia, Rafferty, Mark, Butt, Nauman M., Oh, Stephen T., Wortmann, Friederike, Ungerstedt, Johanna, Guilarte, Mar, Taparia, Minakshi, Kuykendall, Andrew T., Yi, Cecilia Arana, Ogbugo, Princess, Gaudy-Marqueste, Caroline, Mattson, Mattias, Shomali, William, Giannetti, Matthew P., Bidollari, Ilda, Lin, Hui-Min, Sullivan, Erin, Mar, Brenton, Scherber, Robyn, Roche, Maria, Akin, Cem, Maurer, Marcus   +53 more
openaire   +5 more sources