Results 61 to 70 of about 54,144 (209)

Heterogeneous Visible‐Light Photocatalysis in Continuous‐Flow: A Synergistic Strategy for Challenging Trifluoromethylation of α, α‐Diaryl Allylic Alcohols via 1,2‐aryl Migration

Advanced Science, EarlyView.
A continuous‐flow photocatalytic strategy is presented for the efficient synthesis of β‐trifluoromethyl ketones under visible light. Using a recyclable solid photocatalyst and an inexpensive CF3 source, the method enables rapid reactions, easy scale‐up, and smooth integration into multistep flow synthesis of bioactive molecules.
Peiwen Liu, Weiping Zhu, Xuhong Qian, Fang Zhao   +3 more
wiley   +1 more source

Synthesizing regulatory guidance for demonstrating preclinical efficacy and translating promising cell therapies to early phase clinical trials: a scoping review

BMC Medicine
Background Regulatory applications for cell therapy face more objections compared to conventional small molecule or biological drugs, leading to delays in market approval and clinical adoption.
Matthew S. Jeffers, Cheng En Xi, Raj Bapuji, Hannah Wotherspoon, Jonathan Kimmelman, Patrick Bedford, Daniel I. McIsaac, Manoj M. Lalu, Dean A. Fergusson   +8 more
doaj   +1 more source

The central role of mindful parenting in child’s emotional regulation and human flourishing: a blueprint perspective

Frontiers in Psychology
This article provides an innovative perspective of emotional-regulation and human flourishing which acknowledges the fundamental role of early parent–child experiences in shaping brain structure and functioning involved in emotional regulation and the ...
Antonella Sansone
doaj   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

P511: Evaluation of population frequency data for mitochondrial variant interpretation

Genetics in Medicine Open, 2023
Glenn Maston, Pernilla von Nandelstadh, Sari Tuupanen, Izabela Karbassi, Juha Koskenvuo   +4 more
doaj   +1 more source

Impact of CFTR Modulators on Longitudinal Cystic Fibrosis Survival and Mortality: Review and Secondary Analysis

Pulmonary Therapy
Introduction Cystic fibrosis (CF) transmembrane conductance regulator modulators (CFTRm) have transformed CF care, shifting treatment from only managing symptoms to also addressing the underlying defects that cause CF.
Jaime L. Rubin, Craig McKinnon, Gabriel Ghizzi Pedra, Devon A. Morgan, Kimberly Zweig, Theodore G. Liou   +5 more
doaj   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Correction to: Diagnostic utility of next-generation sequencing-based panel testing in 543 patients with suspected skeletal dysplasia

Orphanet Journal of Rare Diseases, 2022
Alicia Scocchia, Tiia Kangas-Kontio, Melita Irving, Matti Hero, Inka Saarinen, Liisa Pelttari, Kimberly Gall, Satu Valo, Johanna M. Huusko, Jonna Tallila, Johanna Sistonen, Juha Koskenvuo, Tero-Pekka Alastalo   +12 more
doaj   +1 more source

DESIGNING SERVICE BLUEPRINT AT THE HOTEL LABORATORY OF CIPUTRA UNIVERSITY

Business and Finance Journal
The tourism industry has recovered from the effect of pandemic covid-19, that makes the stakeholders in the hospitality sector must be able to respond; including hotel managers and higher education institutions that have tourism and hospitality study ...
karina enny agustina, Hermeindito
doaj   +1 more source

Rational Design of Weakly‐Solvating Molecules for Salt‐In‐Pre‐Ionic‐Liquid Electrolytes for Li Metal Batteries

Advanced Science, EarlyView.
The weakly‐solvating TFMSPyr electrolyte tailors the Li+ solvation structure by suppressing solvent coordination and promoting anion‐dominated solvation. This unique solvation environment induces preferential anion decomposition at electrode interfaces, forming robust inorganic rich S/CEI.
Bishnu P. Thapaliya, Vaidyanathan Sethuraman, Naresh C. Osti, Arvind Ganesan, K. Shawn Reeves, Michael J. Zachman, Albina Y. Borisevich, Harry M. Meyer III, Xiao‐Guang Sun, Eugene Mamontov, Lei Cheng, Sheng Dai   +11 more
wiley   +1 more source