Results 91 to 100 of about 36,167 (307)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

"""I been to hear the highest kind of opera grand"": blues, ""good music,"" and the performance of race on record, 1920-1921" [PDF]

, 2010
In the early twentieth century, record companies frequently used the designation “good music” as a catch-all category to describe serious art music selections, and the commercial and cultural value afforded to “good music” becomes audible on early vocal ...
Surles, Elizabeth K.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pengaruh Baby Blues pada Interaksi Ibu dan Kesejahteraan Emosional Anak

Mu'adalah
This article explores the impact of Baby blues on the emotional well-being of young children, focusing on how this condition affects emotional attachment and the quality of interaction between mother and child.
Dyah Ageng Pramesty Koenarso, Ayu Fajarwati, Annisa Herlida Sari   +2 more
doaj   +1 more source

Story of the Blues pre war

, 2014
- Racines africaines du blues ; - Les chanteuses de blues classique ( Bessie Smith, Ma Rainey,…); - Le blues rural ( Mississippi, Texas, East Coast) , - Le blues urbain ( Memphis, Saint Louis, Chicago) pre ...
Sacré, Robert
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

RELATIONSHIP BETWEEN POSTPARTUM ANXIETY AND BABY BLUES SYNDROME AT UNIVERSITAS AIRLANGGA HOSPITAL

Indonesian Midwifery and Health Sciences Journal
Background: Postpartum mothers are vulnerable to mental health problems, including baby blues syndrome, which occurs in the first week. Baby blues syndrome has the potential to predict postpartum depression, and if left untreated, it can lead to more ...
Intan Fairuz Zakia, Dwi Izzati, Atika Atika   +2 more
doaj   +1 more source

J.J. THAMES A Mississippi Blues Diva [PDF]

, 2019
1 )Dossier sur la carrière de la chanteuse J.J. Thames ( soul blues)+ interview + photos 2.
Sacré, Robert
core