Results 101 to 110 of about 36,167 (307)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pengaruh KIE dan Dukungan Suami Terhadap Pencegahan Postpartum Blues pada Ibu Nifas

Jurnal Kesehatan Komunitas (Journal of Community Health)
Jika tidak ditangani, postpartum blues dapat menyebabkan depresi dalam dua minggu pertama setelah melahirkan. Di Indonesia, postpartum blues masih umum terjadi, dan upaya pencegahan berbasis keluarga masih belum lengkap.
Eka Putri Febriyanti, Ryzky Diah Anggraini   +1 more
doaj   +1 more source

Blues Open Air (3rd: 1993)

, 1993
Lineup includes: Philippe Hammel, Luther Allison, Jonni Mac, Baby\u27s First Teddybear, The Lancers, Lazy Poker Blues Band, Inner City Blues Band, Night Trainhttps://egrove.olemiss.edu/bposters_80s90s/1096/thumbnail ...
Basler International Southern Cross Blues Society
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Relationship Between Postpartum Maternity Blues and Breastfeeding

Ebelik ve Sağlık Bilimleri Dergisi
Objective: This study aims to investigate the relationship between postpartum maternity blues and breastfeeding and the effect of maternity blues on breastfeeding. Methods: This cross-sectional was conducted with 302 mothers who applied to Taşköprü State
Elif Velioğlu, Serap Öztürk Altınayak   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Ladies sing the blues

, 2014
Konsert med eget och andras material vid Blues & retrofestivalen i Boden 5 juli 2014.Låtlista:Won't be fooled no more - WedinSolitary one - WedinLet the good times roll - JordanSomething to talk about - RaittThe Weight - Robertson m.fl.Godkänd; 2014;

core   +2 more sources

Management and prevention of Maternity Blues: nurse's role.

, 2023
reservedIntroduzione: La Maternity Blues (MB) è da alcuni anni oggetto di attenzione nel mondo scientifico e della comunità degli operatori sanitari, in virtù del fatto che la gravidanza e il post partum rappresentano uno dei periodi della vita a ...
TUPAZ, MALAIKA LYGREI PINERO
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source