Results 131 to 140 of about 544,641 (311)
Advanced Science, EarlyView.Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang +10 more
wiley +1 more source
Some measurements of the dynamic and static stability of two blunt-nosed, low-fineness- ratio bodies of revolution in free flight at mequal4 [PDF]
Dynamic and static stability of two blunt nosed low fineness ratio bodies of revolution in free flight ...
Short, B. J., Sommer, S. C.
core +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Approximate relations for laminar heat-transfer and shear-stress functions in equilibrium dissociated air [PDF]
Approximate equations for computing enthalpy and velocity derivatives at surface of flat plate, cone, or blunt axisymmetric ...
Zoby, E. V.
core +1 more source
Advanced Science, EarlyView.This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang +6 more
wiley +1 more source
Heat-transfer Measurements on a Blunt Spherical-segment Nose to a Mach Number of 15.1 and Flight Performance of the Rocket-propelled Model to a Mach Number of 17.8 [PDF]
Heat transfer measurements on blunt spherical segment nose and cylindrical body and flight test of rocket-propelled ...
Lee, D. B., Rumsey, C. B.
core +1 more source
Advanced Science, EarlyView.The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen +11 more
wiley +1 more source
Effect of shock precursor heating on radiative flux to blunt bodies [PDF]
Effect of shock precursor heating on radiative flux to blunt ...
Lasher, L. E., Wilson, K. H.
core +1 more source
Advanced Science, EarlyView.The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia +15 more
wiley +1 more source