Results 41 to 50 of about 343,872 (339)

Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth

Vaccines
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8+ T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and ...
Martin R. Ramos-Gonzalez, Mohammad Tarique, Lalit Batra, Feyza Arguc, Rodolfo Garza-Morales, Haval Shirwan, Esma S. Yolcu, Jorge G. Gomez-Gutierrez   +7 more
doaj   +1 more source

Environmental and Pharmacological Manipulations Blunt the Stress Response of Zebrafish in a Similar Manner

Scientific Reports, 2016
Here we provide evidence that both pharmacological and environmental manipulations similarly blunt the cortisol release in response to an acute stressor in adult zebrafish.
A. C. Giacomini, M. Abreu, R. Zanandrea, Natália Saibt, M. T. Friedrich, Gessi Koakoski, Darlan Gusso, A. Piato, L. Barcellos   +8 more
semanticscholar   +1 more source

The NF-κB signaling network in the life of T cells

Frontiers in Immunology
NF-κB is a crucial transcription factor in lymphocyte signaling. It is activated by environmental cues that drive lymphocyte differentiation to combat infections and cancer.
Mark A. Daniels, Mark A. Daniels, Emma Teixeiro, Emma Teixeiro   +3 more
doaj   +1 more source

Evaluation of small-volume (3 ml) ophthalmic anaesthesia for both subtenon anaesthesia using blunt-tipped curved needle and single medial canthal injection with sharp needle for phacoemulsification surgery

Journal of the Egyptian Ophthalmological Society, 2018
Introduction Medial canthus injection as well as subtenon anaesthesia has been used in anterior segment surgery. In this research, we compared the effectiveness and safety of small volume (3 ml) for either technique. Patients and methods Forty eyes of 40
Tamer A Refai, Rehab S Khattab
doaj   +1 more source

Interference Mitigation for GNSS Receivers Using FFT Excision Filtering Implemented on an FPGA

Eng, 2022
GNSS receivers process signals with very low received power levels (
Tasneem Yousif, Paul Blunt
doaj   +1 more source

Pediatric blunt renal trauma with wide fragments dislocation: successful organ saving management by internal stenting and percutaneous perirenal drain

La Pediatria Medica e Chirurgica, 2014
Children have an high risk of renal damage as a result of blunt trauma. Conservative management is always recommended for lower grades (I to III) but is rather controversial whenever high grade injuries (grade IV and V) are concerned.
C. Olivieri, M.G. Grella, V.D. Catania, A.C. Contini, V. Briganti, A. Calisti   +5 more
doaj   +1 more source

Influence of Non-Uniform Bluntness on Aerodynamic Performance and Aerothermal Characteristics of Waverider

Aerospace, 2023
The waverider is widely used in hypersonic vehicles with its high aerodynamic performance, but due to the serious aerothermal environment, its sharp leading edge should be blunted.
Zhipeng Qu, Wanyu Wang, Houdi Xiao, Yao Xiao, Guangli Li, Kai Cui   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Differences in the Evaluation of Prosocial Lies: A Cross-Cultural Study of Canadian, Chinese, and German Adults

Frontiers in Communication, 2019
In daily life, humans often tell lies to make another person feel better about themselves, or to be polite, or socially appropriate in situations when telling the blunt truth would be perceived as inappropriate.
Renuka M. Giles, Kathrin Rothermich, Marc D. Pell   +2 more
doaj   +1 more source