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Recent Advances in BLV Research [PDF]

Viruses, 2015
Different animal models have been proposed to investigate the mechanisms of Human T-lymphotropic Virus (HTLV)-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species ...
Alix De Brogniez, Alexandre Carpentier, Nicolas A Gillet   +2 more
exaly   +6 more sources

Phylogenetic Analysis of South African Bovine Leukaemia Virus (BLV) Isolates

Viruses, 2020
Bovine leukaemia virus (BLV) causes chronic lymphoproliferative disorder and fatal lymphosarcoma in cattle, leading to significant economic losses in the beef and dairy industries. BLV is endemic globally and eleven genotypes have been identified.
Akiko Suzuki, Rosamund Chapman, Nicola Douglass   +2 more
exaly   +2 more sources

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Amperometric immunosensor for diagnosis of BLV infection

Biosensors and Bioelectronics, 2008
A new amperometric immunosensor for detection of antibodies against bovine leukemia protein (gp51) was designed. The detection of antibody-antigen complex formation was based on application of secondary antibodies labeled with horseradish peroxidase (HRP). Ferrocenecarboxylic acid (FCA) and N,N,N',N'-tetramethylbenzidine (TMB) were selected as suitable
Bogumila, Kurtinaitiene, Dovile, Ambrozaite, Valdas, Laurinavicius, Almira, Ramanaviciene, Arunas, Ramanavicius   +4 more
openaire   +2 more sources

The BLV-miRNAs pathway of BLV inhibits the expression of Lactoferrin, Lactoperoxidase, Alpha-lactalbumin and Beta-lactoglobulin proteins

Veterinary Microbiology
Bovine leukemia virus (BLV) is a widespread virus that decreases milk production and quality in dairy cows. As crucial components of BLV, BLV-encoded microRNAs (BLV-miRNAs) affect BLV replication and may impact the synthesis of Lactoferrin (LTF), Lactoperoxidase (LPO), Alpha-lactalbumin (alpha-LA), and Beta-lactoglobulin (beta-LG).
Jianfa Wang
exaly   +3 more sources

Elicitation of bovine antibody to BLV-gp51 by BLV-vaccination.

Leukemia, 1989
This study was carried out to demonstrate sequential changes of antibody response to gp51 of BLV in bovine hosts injected with BLV-vaccine. BLV vaccine was prepared from culture fluids from FLK-BLV cells by treatment with 0.1% formalin for 48 hrs at 4 degrees C followed by ultrafiltration and lyophilization. Sterile vaccine containing 300 mg protein/ml,
K, Maruyama, T, Fukushima, S, Mochizuki, H, Abe, M, Onuma, A, Hasegawa, M, Misawa   +6 more
openaire   +1 more source

Investigations of the Japanese Bovine Tumour Virus (BLV)-its Ability to Express Structural and Regulatory BLV Proteins

Journal of Veterinary Medicine, Series B, 1996
The mechanism of BLV-induced tumorigenesis has not been clear up to now. Changes of viral protein expression in infected cells may be involved in the molecular events leading to BLV-induced leukaemogenesis. In this study Western blot investigations of cells transfected with plasmid DNA containing the complete Japanese BLV tumour clone provirus ...
P, Blankenstein, A, Bondzio, A, Büchel, E, Kinder, D, Ebner   +4 more
openaire   +2 more sources

Augmentation of Bovine Leukemia Virus (BLV)‐Specific Lymphocyte Proliferation Responses in Ruminants by Inoculation with BLVenv‐Recombinant Vaccinia Virus: Their Role in the Suppression of BLV Replication

Microbiology and Immunology, 1992
AbstractLymphocyte proliferation responses were investigated in sheep and cattle, in which the replication of bovine leukemia virus (BLV) had been known to be suppressed by inoculation with recombinant vaccinia virus (rVV) expressing BLV envelope glycoprotein (gp60).
K, Ohishi, H, Suzuki, Y, Yasutomi, M, Onuma, K, Okada, S, Numakunai, K, Ohshima, Y, Ikawa, M, Sugimoto   +8 more
openaire   +2 more sources

The BLV-induced leukemia-lymphosarcoma complex in sheep

Veterinary Immunology and Immunopathology, 1989
Sheep are highly susceptible to BLV infection and can be infected via several different means (routes). In all inoculated animals, specific anti-BLV antibodies can be demonstrated 1 to 3 months post-inoculation (p.i.). Between 10 and 13 months p.i., a moderate but persistent lymphocytosis (PL) may be detected in about 50% of the infected animals.
S, Djilali, A L, Parodi
openaire   +2 more sources