Results 1 to 10 of about 3,180,845 (188)

HTLV-1 Proviral Load in Vaginal Fluid Correlates with Levels in Peripheral Blood Mononuclear Cells [PDF]

Pathogens, 2023
Background: The prevalence of human T-lymphotropic virus type-1 (HTLV-1) infection is higher in women, and sexual intercourse has been described as an important route of male-to-female transmission.
Alisson de Aquino Firmino, Paulo Roberto Tavares Gomes Filho, Adenilda Lima Lopes Martins, Thessika Hialla Araújo, Luana Leandro Gois, Everton da Silva Batista, Jean Paulo Lacerda Araújo, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi   +8 more
doaj   +6 more sources

Association between bovine leukemia virus proviral load and severity of clinical mastitis [PDF]

Journal of Veterinary Medical Science, 2019
The purpose of this study was to clarify the effect of Bovine leukemia virus (BLV) infection on natural immunity in the bovine mammary gland and on the severity of clinical mastitis. We classified milk samples from clinical mastitic cows into BLV-positive (n=76) and BLV-negative (n=12).
Naoki Isobe, Takahiro Seto, Yasunori Shinozuka   +2 more
exaly   +6 more sources

Development of a predictive model for bovine leukemia virus proviral load. [PDF]

J Vet Intern Med, 2022
Abstract Background There is currently no commercially available method in Canada to identify bovine leukemia virus (BLV)-positive cows with high proviral load (PVL). Objectives First, develop a model to predict PVL ...
John EE, Droscha C, Cameron M, Stryhn H, Keefe G, McClure JT.   +5 more
europepmc   +5 more sources

Dolutegravir use is related to lower HTLV-1 proviral load in people co-infected by HIV-1 [PDF]

Communications Medicine
Background Infection by human T-cell lymphotropic virus type 1 (HTLV-1) affects millions of people worldwide and causes severe diseases. To date, no specific treatment is available for HTLV infection. The purpose of this study was to determine the impact
Tatiana Fernandez, María B. Arriaga, Rafaela Mayoral, Eduardo M. Netto, Carlos Brites   +4 more
doaj   +3 more sources

Development of a droplet digital PCR assay for quantification of the proviral load of bovine leukemia virus. [PDF]

J Vet Diagn Invest, 2022
Droplet digital PCR (ddPCR) is a highly sensitive tool developed for the detection and quantification of short-sequence variants—a tool that offers unparalleled precision enabling measurement of smaller-fold changes. We describe here the use of ddPCR for the detection of Bovine leukemia virus (BLV) DNA provirus.
De Brun ML, Cosme B, Petersen M, Alvarez I, Folgueras-Flatschart A, Flatschart R, Panei CJ, Puentes R.   +7 more
europepmc   +5 more sources

The SAMHD1 rs6029941 (A/G) Polymorphism Seems to Influence the HTLV-1 Proviral Load and IFN-Alpha Levels [PDF]

Frontiers in Cellular and Infection Microbiology, 2020
SAMHD1, a host dNTPase, acts as a retroviral restriction factor by degrading the pool of nucleotides available for the initial reverse transcription of retroviruses, including HTLV-1.
Maria Alice Freitas Queiroz, Ednelza da Silva Graça Amoras, Tuane Carolina Ferreira Moura, Carlos Araújo da Costa, Maisa Silva de Sousa, Sandra Souza Lima, Ricardo Ishak, Antonio Carlos Rosário Vallinoto   +7 more
doaj   +3 more sources

Cognitive impairment in HTLV-1-associated myelopathy, proviral load and inflammatory markers [PDF]

International Journal of Infectious Diseases, 2019
Objectives: Myelopathy is a well-established long-term clinical manifestation of HTLV-1 infection. Besides motor dysfunction, cognitive impairment may be another consequence of HTLV-1 infection.
Ana Paula Silva Champs, Valéria Maria de Azeredo Passos, Guilherme Carvalho, Sandhi Maria Barreto, Carla Meirelles, Paulo Caramelli   +5 more
doaj   +4 more sources

Quantification of HTLV-I proviral load in experimentally infected rabbits [PDF]

Retrovirology, 2005
Background Levels of proviral load in HTLV-1 infected patients correlate with clinical outcome and are reasonably prognostic. Adaptation of proviral load measurement techniques is examined here for use in an experimental rabbit model of HTLV-1 infection.
Kindt Thomas J, Simpson R Mark, Caudell David L, Hague Bishop, Zhao Tong-Mao   +4 more
doaj   +3 more sources

Identification of BoLA Alleles Associated with BLV Proviral Load in US Beef Cows. [PDF]

Pathogens, 2022
Bovine leukemia virus (BLV) causes enzootic bovine leukosis, the most common neoplastic disease in cattle. Previous work estimates that 78% of US beef operations and 38% of US beef cattle are seropositive for BLV. Infection by BLV in a herd is an economic concern for producers as evidence suggests that it causes an increase in cost and a subsequent ...
LaHuis CH, Benitez OJ, Droscha CJ, Singh S, Borgman A, Lohr CE, Bartlett PC, Taxis TM.   +7 more
europepmc   +4 more sources

Point-of-Care System for HTLV-1 Proviral Load Quantification by Digital Mediator Displacement LAMP. [PDF]

Micromachines (Basel), 2021
This paper presents a universal point-of-care system for fully automated quantification of human T-cell lymphotropic virus type 1 (HTLV-1) proviral load, including genomic RNA, based on digital reverse RNA transcription and c-DNA amplification by MD LAMP (mediator displacement loop-mediated isothermal amplification).
Becherer L, Hess JF, Frischmann S, Bakheit M, Nitschko H, Stinco S, Zitz F, Hofer H, Porro G, Hausladen F, Stock K, Drossart D, Wurm H, Kuhn H, Huber D, Hutzenlaub T, Paust N, Keller M, Strohmeier O, Wadle S, Borst N, Zengerle R, von Stetten F.   +22 more
europepmc   +6 more sources