Results 21 to 30 of about 3,180,845 (188)

BoLA-DRB3 Polymorphism Controls Proviral Load and Infectivity of Bovine Leukemia Virus (BLV) in Milk. [PDF]

Pathogens, 2022
Bovine leukemia virus (BLV), which causes enzootic bovine leukosis, is transmitted to calves through the milk of BLV-infected dams. Bovine leukocyte antigen (BoLA)-DRB3 is a polymorphic gene associated with BLV infectivity and proviral load (PVL ...
Nakatsuchi A, Watanuki S, Borjigin L, Sato H, Bai L, Matsuura R, Kuroda M, Murakami H, Sato R, Asaji S, Ando A, Matsumoto Y, Takeshima SN, Aida Y.   +13 more
europepmc   +2 more sources

High HTLV-1 Proviral Load Predates and Predicts HTLV-1-Associated Disease: Literature Review and the London Experience. [PDF]

Pathogens
Human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects lymphocytes and causes severe diseases. HTLV-1 proviral load (PVL), i.e., the number of host cells that carry HTLV-1 proviral DNA integrated into their genome, can be measured ...
Taylor GP, Evans W, Rosadas C.
europepmc   +2 more sources

Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia. [PDF]

Viruses, 2022
Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL.
Kato M, Imaizumi N, Tanaka R, Mizuguchi M, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Todoroki J, Karube K, Masuzaki H, Tanaka Y, Fukushima T.   +12 more
europepmc   +2 more sources

Single Nucleotide Polymorphisms in Genes Encoding Toll-Like Receptors 7 and 8 and Their Association with Proviral Load of SRLVs in Goats of Polish Carpathian Breed. [PDF]

Animals (Basel), 2021
Simple Summary The purpose of the study was to identify SNPs in genes encoding TLR7 and TLR8 in goats of Carpathian breed and analyze their association with the SRLVs provirus concentration. A total of 14 SNPs were detected, 6 SNPs in the TLR7 gene locus
Olech M, Ropka-Molik K, Szmatoła T, Piórkowska K, Kuźmak J.   +4 more
europepmc   +2 more sources

Anti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma. [PDF]

Cancer Sci, 2023
Human T‐cell leukemia virus type 1 (HTLV‐1) establishes chronic infection in humans and induces a T‐cell malignancy called adult T‐cell leukemia‐lymphoma (ATL) and several inflammatory diseases such as HTLV‐1‐associated myelopathy/tropical spastic ...
Yamada A, Yasunaga JI, Liang L, Zhang W, Sunagawa J, Nakaoka S, Iwami S, Kogure Y, Ito Y, Kataoka K, Nakagawa M, Iwanaga M, Utsunomiya A, Koh KR, Watanabe T, Nosaka K, Matsuoka M.   +16 more
europepmc   +2 more sources

Longitudinal comparison of HIV‐1 plasma viral load and cellular proviral load [PDF]

Journal of the International AIDS Society, 2014
IntroductionThe goal of antiretroviral treatment (ART) in HIV‐1 infection is the permanent suppression of plasma viral load (pVL) below the currently existing limit of detection of 50 copies/mL (DAIG HIV‐therapy guidelines). Therefore, treatment effectiveness is based on pVL.
Schweitzer, Finja, Mikkola, Visa, Timmen-Wego, Monika, Jensen, Björn, Fätkenheuer, Gerd, Kaiser, Rolf   +5 more
openaire   +2 more sources

Development of droplet digital PCR for quantification of bovine leukemia virus proviral load using unpurified genomic DNA.

Journal of Virological Methods, 2023
Bovine leukemia virus (BLV) is the causative agent of a B-cell tumor called enzootic bovine leukosis. Preventing BLV spreading is required to reduce economic loss related to BLV infection of livestock.
Xinyue Wu, Kousuke Notsu, Y. Matsuura, Shuya Mitoma, Hala El Daous, J. Norimine, S. Sekiguchi   +6 more
semanticscholar   +1 more source

Impact of high proviral load on milk production, reproduction and subclinical diseases in dairy cows infected with bovine leukemia virus [PDF]

Frontiers in Veterinary Science
Bourassi S, McKenna S, Keefe G, John E, VanLeeuwen J, Bourassi E, McClure JT.   +6 more
exaly   +2 more sources

Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.

Infection, Genetics and Evolution, 2022
Background HTLV-1-associated myelopathy (HAM/TSP) is a progressive neurodegenerative inflammatory condition of HTLV-1 infection. Viral-host interactions are a significant contributor to the symptoms of HTLV-1-associated diseases. Therefore, in this study,
Mona Saffari, Masooma Rahimzada, A. Mirhosseini, Sanaz Ahmadi Ghezaldasht, N. Valizadeh, M. Moshfegh, M. Moradi, S. Rezaee   +7 more
semanticscholar   +1 more source

HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM/TSP. [PDF]

PLoS Pathogens, 2008
Human T-lymphotropic virus type 1 (HTLV-1) causes leukaemia or chronic inflammatory disease in approximately 5% of infected hosts. The level of proviral expression of HTLV-1 differs significantly among infected people, even at the same proviral load ...
Kiran N Meekings, Jeremy Leipzig, Frederic D Bushman, Graham P Taylor, Charles R M Bangham   +4 more
doaj   +1 more source