Results 1 to 10 of about 1,686 (163)

Progress in the clinical use of bone marrow aspirate concentrate for knee osteoarthritis: an expert opinion [PDF]

Journal of Orthopaedic Surgery and Research
Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability. Orthobiological therapies aim to regenerate articular cartilage and delay or stop the progression of the degenerative lesion. Intra-articular injections of
Filippo Migliorini, Marco Pilone, Francesco Simeone, Madhan Jeyaraman, Andreas Bell, Nicola Maffulli   +5 more
doaj   +2 more sources

Short-Term Cryopreservation Preserved the Function of MSCs from Bone Marrow Aspirate Concentrate [PDF]

Cells
Bone marrow aspirate concentrate (BMAC) is increasingly recognized as a valuable orthobiologic, offering promising outcomes in reducing inflammation, alleviating pain for patients with osteoarthritis (OA) and various musculoskeletal conditions.
Jacob Singer, Haruki Nishimura, Zuokui Xiao, Xueqin Gao, Noah Knezic, Laura Chubb, Jonathan E. Layne, Ping Guo, Aiping Lu, Johnny Huard   +9 more
doaj   +2 more sources

Optimal timing of bone marrow aspiration concentrate injection for tendon-bone healing in a chronic rat rotator cuff tear model [PDF]

Journal of Orthopaedic Surgery and Research
Background The Bone marrow aspirate concentrate (BMAC) injection is a beneficial therapy for bone-tendon interface (BTI) regeneration following rotator cuff (RC) repair. However, the optimal timing for BMAC injection remains undetermined.
Congyang Wang, Hao Zeng, Qiang Shi, Hua Jiang   +3 more
doaj   +2 more sources

Single-cell transcriptomics of multi-site cell therapy in osteoarthritis: Tissue-specific treatment correlations [PDF]

Molecular Therapy: Nucleic Acids
Knee-osteoarthritis (knee OA) is a prevalent joint disorder lacking Food and Drug Administration-approved cell therapies to halt progression. This study uses single-cell RNA sequencing to analyze bone marrow aspirate concentrate (BMAC) and stromal ...
Paramita Chatterjee, Hazel Y. Stevens, Linda E. Kippner, Carolyn Yeago, Hicham Drissi, Kenneth Mautner, Scott D. Boden, Greg Gibson, Krishnendu Roy   +8 more
doaj   +2 more sources

Bone Marrow Aspirate Concentrate (BMAC) for Knee Osteoarthritis: A Narrative Review of Clinical Efficacy and Future Directions [PDF]

Medicina
Bone marrow aspirate concentrate (BMAC) is an autologous regenerative therapy enriched with mesenchymal stem cells (MSCs) and bioactive growth factors, offering potential disease-modifying effects in knee osteoarthritis (OA).
Dojoon Park, Hae-Seok Koh, Youn-Ho Choi, Ilkyu Park   +3 more
doaj   +2 more sources

Autologous Bone Marrow Aspirate Stem Cell Concentrate (BMAC) for treatment of patients with Fontaine stages III-IV peripheral arterial disease: a pilot safety and feasibility study [PDF]

CellR4, 2021
Objective: Peripheral arterial disease (PAD) is a chronic arterial occlusive disease which mostly affects the arteries of the lower extremities. PAD morbidity generally ranges from 3% to 10%, although it increases with advancing age and can be greater ...
M. Donoso, I. Martinez, M. Palma Fariñas, O. Cosin, S. Fernandez, A. Belenguer, M. Fernández Viña   +6 more
doaj   +1 more source

Genetic analysis of a bronze age individual from Ulug-depe (Turkmenistan)

Frontiers in Genetics, 2022
The Oxus Civilisation (or Bactrio-Margian Archaeological Complex, BMAC) was the main archaeological culture of the Bronze Age in southern Central Asia. Paleogenetic analyses were previously conducted mainly on samples from the eastern part of BMAC.
Perle Guarino-Vignon, Perle Guarino-Vignon, Nina Marchi, Amélie Chimènes, Aurore Monnereau, Aurore Monnereau, Sonja Kroll, Marjan Mashkour, Johanna Lhuillier, Julio Bendezu-Sarmiento, Evelyne Heyer, Céline Bon   +11 more
doaj   +1 more source

Intraosseous Injection of Autologous Bone Marrow Aspirate Concentrate and Platelet-Rich Plasma for Treatment of Knee Osteoarthritis [PDF]

Travmatologiâ i Ortopediâ Rossii, 2021
The aim of the study was to determine the effectiveness of autologous bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) intraosseous injection in the treatment of patients with knee OA stages II-III.
Dmitriy A. Malanin, Vladimir D. Sikilinda, Andrei I. Gorbatenko, Maxim V. Demeshchenko, Il’ya A. Suchilin, Vladimir V. Kondrashenko, Nataliya O. Kostyanaya   +6 more
doaj   +1 more source

Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy

Frontiers in Veterinary Science, 2021
This retrospective study aimed to evaluate the clinical effect of bone marrow aspirate concentrate (BMAC) and leukocyte rich PRP (LR-PRP) compared to horses undergoing controlled exercise alone in horses with >3 months proximal suspensory desmopathy ...
Grigorios Maleas, Mahmoud Mageed
doaj   +1 more source

Bone Marrow Aspirate Concentrate versus Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells for Combined Cartilage Regeneration Procedure in Patients Undergoing High Tibial Osteotomy: A Systematic Review and Meta-Analysis

Medicina, 2023
Background and objectives: Cartilage regeneration using mesenchymal stem cells (MSCs) has been attempted to improve articular cartilage regeneration in varus knee osteoarthritis (OA) patients undergoing high tibial osteotomy (HTO).
Dojoon Park, Youn Ho Choi, Se Hyun Kang, Hae Seok Koh, Yong In   +4 more
doaj   +1 more source