Results 41 to 50 of about 3,948 (257)
Microbiology Spectrum, 2021 The signal peptide (SP) of integrated membrane proteins is removed cotranslationally or posttranslationally in the endoplasmic reticulum, while GP64, a membrane fusion protein of Bombyx mori nucleopolyhedrovirus (BmNPV), retains its SP in the mature ...
Bifang Hao +5 more
doaj +1 more source
Molecular Plant Pathology, Volume 22, Issue 9, Page 1070-1081, September 2021., 2021 N6 methylation of adenosine modification might be the epigenetic mechanism that regulates rice black streaked dwarf virus replication in its insect vector and maintains a certain virus threshold for persistent transmission. Abstract N6 methylation of adenosine (m6A) was recently discovered to play a role in regulating the life cycle of various viruses ...
Shuping Tian +3 more
wiley +1 more source
Viruses, 2022 Bombyx mori nucleopolyhedrovirus (BmNPV) is a pathogen that causes severe disease in silkworms. In a previous study, we demonstrated that by using the CRISPR/Cas9 system to disrupt the BmNPV ie-1 and me53 genes, transgenic silkworms showed resistance to ...
Yujia Liu +12 more
doaj +1 more source
Viruses, 2022 Bombyx mori nucleopolyhedrovirus (BmNPV), a typical arthropod-specific enveloped DNA virus, is one of the most serious pathogens in silkworm farming, but the potential mechanisms of the evasion of innate immune responses from BmNPV infection are still ...
Guanping Chen +5 more
doaj +1 more source
CRISPR/Cas12a Mediated Genome Editing Enhances Bombyx mori Resistance to BmNPV [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 CRISPR/Cas12a (Cpf1) is a single RNA-guided endonuclease that provides new opportunities for targeted genome engineering through the CRISPR/Cas9 system. Only AsCas12a has been developed for insect genome editing, and the novel Cas12a orthologs nucleases and editing efficiency require more study on insects.
Zhanqi Dong +10 more
openaire +3 more sources
Knockdown of BmTCP-1β Delays BmNPV Infection in vitro [PDF]
Frontiers in Microbiology, 2019 The molecular mechanism of silkworm resistance to Bombyx mori nucleopolyhedrovirus (BmNPV) infection remains unclear. The chaperonin containing t-complex polypeptide 1 (TCP-1) is essential for the folding of tubulin and actin to produce stable and functional competent protein conformation. However, little is known about this protein in silkworm. In the
Xue-yang Wang +12 more
openaire +3 more sources
Genome-Wide Analysis of Differentially Expressed microRNA in Bombyx mori Infected with Nucleopolyhedrosis Virus. [PDF]
PLoS ONE, 2016 Bombyx mori nucleopolyhedrosis virus (BmNPV) is a major pathogen that threatens the growth and sustainability of the sericulture industry. Since microRNAs (miRNAs) have been shown to play important roles in host-pathogen interactions, in this study we ...
Ping Wu +4 more
doaj +1 more source
Phenotypic grouping of 141 BmNPVs lacking viral gene sequences [PDF]
Virus Research, 2012 We constructed a series of gene knockout BmNPVs (KOVs) for each of 141 genes (Gomi et al., 1999; Katsuma et al., 2011) using the BmNPV T3 bacmid system (Ono et al., 2007) and lambda red recombination system (Datsenko and Wanner, 2000). In a subsequent analysis of the properties needed for infection using a marker gene, egfp (enhanced green fluorescent ...
Ono, Chikako +5 more
openaire +3 more sources
Regulation of <i>Bombyx mori</i>-BmNPV Protein Interactions: Study Strategies and Molecular Mechanisms. [PDF]
VirusesGuo D, Liu B, Cui M, Qian H, Li G.
europepmc +3 more sources
An efficient algorithm for optimizing whole genome alignment with noise [PDF]
, 2004 Motivation: This paper is concerned with algorithms for aligning two whole genomes so as to identify regions that possibly contain conserved genes. Motivated by existing heuristic-based software tools, we initiate the study of an optimization problem ...
Lam, TW +4 more
core +1 more source