Results 1 to 10 of about 39,940 (191)
Baculovirus as a Tool for Gene Delivery and Gene Therapy
Viruses, 2018 Based on its ability to express high levels of protein, baculovirus has been widely used for recombinant protein production in insect cells for more than thirty years with continued technical improvements.
Yoshiharu Matsuura +2 more
exaly +3 more sources
Monobac System–A Single Baculovirus for the Production of rAAV
Microorganisms, 2021 Large-scale manufacturing of rAAV is a bottleneck for the development of genetic disease treatments. The baculovirus/Sf9 cell system underpins the first rAAV treatment approved by EMA and remains one of the most advanced platforms for rAAV manufacturing.
Otto-Wilhelm Merten +2 more
exaly +3 more sources
Viruses, 2023 Baculovirus expression system1s are a widely used tool in recombinant protein and biologics production. To enable the possibility of genome modifications unconstrained through low-throughput and bespoke classical genome manipulation techniques, we set ...
Christopher Nguyen +2 more
doaj +1 more source
Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells. [PDF]
PLoS ONE, 2009 The prototype baculovirus, Autographa californica multiple nucleopolyhedrovirus, an insect pathogen, holds great potential as a gene therapy vector. To develop transductional targeting and gene delivery by baculovirus, we focused on characterizing the ...
Johanna P Laakkonen +10 more
doaj +1 more source
Advances in the Arms Race Between Silkworm and Baculovirus
Frontiers in Immunology, 2021 Insects are the largest group of animals. Nearly all organisms, including insects, have viral pathogens. An important domesticated economic insect is the silkworm moth Bombyx mori. B.
Liang Jiang +4 more
doaj +1 more source
Significant productivity improvement of the baculovirus expression vector system by engineering a novel expression cassette. [PDF]
PLoS ONE, 2014 Here we describe the development of a baculovirus vector expression cassette containing rearranged baculovirus-derived genetic regulatory elements. This newly designed expression cassette conferred significant production improvements to the baculovirus ...
Silvia Gómez-Sebastián +2 more
doaj +1 more source
PLoS ONE, 2018 The human Adeno-Associated Virus serotype 2 (wtAAV2) is a common non-pathological virus and its recombinant form (rAAV) is widely used as gene therapy vector. Although rAAVs are routinely produced in the Baculovirus/Sf9 cell system, wtAAV2 has never been
Adrien Savy +5 more
doaj +1 more source
Quantitative proteomics of Spodoptera frugiperda cells during growth and baculovirus infection. [PDF]
PLoS ONE, 2011 Baculovirus infection of Spodoptera frugiperda cells is a system of choice to produce a range of recombinant proteins, vaccines and, potentially, gene therapy vectors. While baculovirus genomes are well characterized, the genome of S.
Nuno Carinhas +6 more
doaj +1 more source
BMC Genomics, 2018 Background Erinnyis ello granulovirus (ErelGV) is a betabaculovirus infecting caterpillars of the sphingid moth E. ello ello (cassava hornworm), an important pest of cassava crops (Manihot esculenta).
A. F. Brito +5 more
doaj +1 more source
The baculovirus uses a captured host phosphatase to induce enhanced locomotory activity in host caterpillars. [PDF]
PLoS Pathogens, 2012 The baculovirus is a classic example of a parasite that alters the behavior or physiology of its host so that progeny transmission is maximized. Baculoviruses do this by inducing enhanced locomotory activity (ELA) that causes the host caterpillars to ...
Susumu Katsuma +5 more
doaj +1 more source