Results 1 to 10 of about 87,018 (285)

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine [PDF]

Frontiers in Pharmacology, 2022
Diabetic kidney disease is one of the most serious microvascular complications of diabetes. It progresses irreversibly to end-stage renal disease if left untreated. Bone morphogenetic protein (BMP)-7 is a negative regulator of organ fibrosis and may also
Yawen Xiao, Yawen Xiao, Dan Liang, Dan Liang, Zhiyang Li, Zhiyang Li, Zhaowei Feng, Zhaowei Feng, Zhiping Yuan, Fan Zhang, Fan Zhang, Yuanyuan Wang, Yuanyuan Wang, Yuxia Zhou, Yuxia Zhou, Mingjun Shi, Mingjun Shi, Lingling Liu, Lingling Liu, Ying Xiao, Ying Xiao, Bing Guo, Bing Guo   +22 more
doaj   +2 more sources

BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages [PDF]

Heliyon, 2023
Background: Although the exosomes derived from mesenchymal stem cells (MSCs) display a therapeutic effect on inflammatory diseases, its application on OA has great limitations due to lack of specificity and targeting. The current study aimed to elucidate
Weixue Sun, Shaozheng Qu, Mingxia Ji, Yanli Sun, Baiqiang Hu   +4 more
doaj   +2 more sources

Sustained delivery of the bone morphogenetic proteins BMP-2 and BMP-7 for cartilage repair and regeneration in osteoarthritis [PDF]

Osteoarthritis and Cartilage Open, 2022
Objective: Attempts to utilise growth factors (GF) such as bone morphogenic proteins (BMPs) to treat osteoarthritis (OA) in the clinic have not secured widespread adoption. However, the novel crystalline GF formulation called PODS offers new perspectives.
Ciara Whitty, Christian Pernstich, Charlotte Marris, Andrew McCaskie, Michael Jones, Frances Henson   +5 more
doaj   +2 more sources

Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults [PDF]

Annals of Geriatric Medicine and Research
Background In vitro and animal studies have demonstrated that bone morphogenetic protein-7 (BMP-7), renowned for its osteogenic properties, also exerts beneficial effects on muscle metabolism by enhancing myogenesis and reversing muscle atrophy.
Ahin Choi, Ji Yeon Baek, Eunhye Ji, Il-Young Jang, Hee-Won Jung, So Jeong Park, Yunju Jo, Eunju Lee, Dongryeol Ryu, Beom-Jun Kim   +9 more
doaj   +2 more sources

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease [PDF]

Cell Death and Disease, 2022
Tubulointerstitial fibrosis (TIF) is involved in the development of diabetic kidney disease (DKD). Transforming growth factor β1 (TGF-β1) is involved in the extensive fibrosis of renal tissue by facilitating the partial epithelial-mesenchymal transition (
Wei Peng, Xingcheng Zhou, Tingting Xu, Yanwen Mao, Xiaohuan Zhang, Huiming Liu, Luqun Liang, Lingling Liu, Lirong Liu, Ying Xiao, Fan Zhang, Shuang Li, Mingjun Shi, Yuxia Zhou, Lei Tang, Yuanyuan Wang, Bing Guo   +16 more
doaj   +2 more sources

BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway. [PDF]

Mol Med Rep, 2017
Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells.
Guo J, Lin Q, Shao Y, Rong L, Zhang D.
europepmc   +4 more sources

BMP-7/Smad expression in dedifferentiated Schwann cells during axonal regeneration and upregulation of endogenous BMP-7 following administration of PTH (1-34) [PDF]

Journal of Orthopaedic Surgery, 2018
Purpose: To determine the expression and distribution of bone morphogenetic protein (BMP)-7 and related molecules during peripheral nerve regeneration and to assess whether administration of parathyroid hormone (PTH) drug (1-34) potentiates the intrinsic
Naoki Kokubu, Masaya Tsujii, Koji Akeda, Takahiro Iino, Akihiro Sudo   +4 more
doaj   +3 more sources

Pediatric Pulmonary Hypertension is Associated With Increased Circulating Levels of BMP 7 and CHIP [PDF]

Pulmonary Circulation
Pulmonary arterial endothelial and smooth muscle cell homeostasis is regulated through the bone morphogenetic protein (BMP) and transforming growth factor beta (TGF‐β) receptor pathways. Pathway imbalance results in pulmonary hypertension (PH).
Edward C. Kirkpatrick, Stephanie Handler, Melodee Liegl, Amy Y. Pan, G. Ganesh Konduri, Todd M. Gudausky, Adeleye J. Afolayan   +6 more
doaj   +2 more sources

The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix [PDF]

Journal of Biological Chemistry, 2005
Biochemical and biophysical methods are used to show that BMP-7 is secreted as a stable complex consisting of the processed growth factor dimer noncovalently associated with its two prodomain propeptide chains and that the BMP-7 complex is structurally similar to the small transforming growth factor beta (TGFbeta) complex.
Kate E, Gregory, Robert N, Ono, Noe L, Charbonneau, Chiu-Liang, Kuo, Douglas R, Keene, Hans Peter, Bächinger, Lynn Y, Sakai   +6 more
openaire   +2 more sources

CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy [PDF]

Journal of the American Society of Nephrology, 2008
In diabetic nephropathy, connective tissue growth factor (CTGF) is upregulated and bone morphogenetic protein 7 (BMP-7) is downregulated. CTGF is known to inhibit BMP-4, but similar cross-talk between BMP-7 and CTGF has not been studied. In this study, it was hypothesized that CTGF acts as an inhibitor of BMP-7 signaling activity in diabetic ...
Nguyen, T.Q., Roestenberg, P.M.H., Roestenberg, P.M.H., van Nieuwenhoven, F.A., Bovenschen, N., Li, Z., Xu, L., Oliver, N, Aten, J., Joles, J., Vial, C., Brandan, E., Lyons, K.M., Goldschmeding, R.   +13 more
openaire   +10 more sources