Results 201 to 210 of about 148,190 (307)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

THR-123, a novel BMP-7 mimetic that activates Akt phosphorylation and inhibits cardiomyocyte apoptosis and inflammation, protects the heart from myocardial injury in a Rat model. [PDF]

Front Cardiovasc Med
Bosukonda D, Subramanian RR, Keck PC, Bey P, Carlson FR, Carlson WD.   +5 more
europepmc   +1 more source

AI‐Ready Bureaucracies? Assessing Capacity‐Building Approaches in European National AI Strategies

Public Administration and Development, EarlyView.
ABSTRACT The global expansion of Artificial Intelligence (AI) strategies is reshaping expectations about state capacity, yet the role of civil servants in this transition remains insufficiently theorized. This study examines how EU Member States address the civil service workforce in their national AI strategies, employing content and cluster analysis ...
Manuel Pedro Rodríguez Bolívar, Sergio Medina‐Bernabé, J. Ignacio Criado   +2 more
wiley   +1 more source

Tuning BMP-Regulated Cell Differentiation in the Aortic Media by Mutating Matrix Gla Protein. [PDF]

Arterioscler Thromb Vasc Biol
Cai X, Gunasinghe KKJ, Qi L, Zhang L, Wu X, Jing Z, Zhao Y, Kim H, Yao E, Hsiai TK, Rahman T, Chee XW, Yao Y, Boström KI.   +13 more
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study. [PDF]

BMC Oral Health
Elmesellawy MY, Wahby MAR, Abuelezz AH.
europepmc   +1 more source

Current Trends and Future Prospects of Integrating Electrospinning With 3D Printing Techniques for Mimicking Bone Extracellular Matrix Scaffolds

Journal of Polymer Science, Volume 63, Issue 6, Page 1481-1504, 15 March 2025.
ABSTRACT This article presents a review of the recent findings on the combination of electrospun nanofibers and three‐dimensional (3D)‐printed structures for extracellular matrix (ECM) scaffolds for bone tissue engineering. We explore the synergy between electrospinning (ES), which produces highly porous, fibrous structures from materials like collagen
Kardo Khalid Abdullah, Kolos Molnár
wiley   +1 more source

Stabilization of Bone Morphogenetic Protein-2 at Physiological pH: Contrasting Roles of CHAPS and Arginine in Aggregation Inhibition. [PDF]

Proteins
Amir H, Roy B, Gaur A, Deep S.
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source