Results 251 to 260 of about 225,133 (281)
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Heparin inhibits BMP‐2 osteogenic bioactivity by binding to both BMP‐2 and BMP receptor
Journal of Cellular Physiology, 2008AbstractHeparin demonstrates several kinds of biological activities by binding to various extracellular molecules and plays pivotal roles in bone metabolism. However, the role of heparin in the biological activity of bone morphogenetic protein (BMP) remains unclear.
Shin, Kanzaki +6 more
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BMP and BMP Regulation: Structure and Function
2017Due to their vast roles in human development, differentiation, homeostasis, and disease, bone morphogenetic proteins (BMP) have evolved along with numerous potentiating and inhibitory mechanisms to fine-tune signaling outcomes. As such, this chapter focuses on some of the best-studied and utilized extracellular mechanisms of BMP signal regulation.
Kristof Nolan, Thomas B. Thompson
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BMP Signaling and Skeletogenesis
Annals of the New York Academy of Sciences, 2006Abstract: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)‐β superfamily of signal molecules that mediate many diverse biological processes ranging from early embryonic tissue patterning to postnatal tissue homeostasis. BMPs trigger cell responses mainly through the canonical signaling pathway where intracellular
Xuelin, Li, Xu, Cao
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Injury, 2005
Bone morphogenetic proteins (BMPs) are polypeptides discovered by Marshall Urist in 1965 and later defined by his co-workers as multifunctional cytokines involved in osteoinduction. They are members of the transforming growth factor-beta superfamily with the exception of the BMP-1.
De Biase, Pietro, Capanna, Rodolfo
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Bone morphogenetic proteins (BMPs) are polypeptides discovered by Marshall Urist in 1965 and later defined by his co-workers as multifunctional cytokines involved in osteoinduction. They are members of the transforming growth factor-beta superfamily with the exception of the BMP-1.
De Biase, Pietro, Capanna, Rodolfo
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BRAM1, a BMP receptor‐associated molecule involved in BMP signalling
Genes to Cells, 1998BackgroundTGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors.
K, Kurozumi +5 more
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Human osteophytes produce BMP-3 & BMP-7
Bone (New York, N.Y.), 1999Osteophytes are newly formed osseous and cartilaginous tissue outgrowths forming mostly at the margin of osteoarthrotic joints. They are extremely variable and irregular in size and shape but it seems that they develope and growth by the same processes of intramembranous and endochondral ossification as bones in embryonal development.
Zoričić Cvek, Sanja +3 more
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Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair
Bone, 2010Bone morphogenetic proteins (BMPs) are potent bone inducers used clinically to enhance fracture repair. BMPs have been shown to be produced in the fracture callus; however, the comparative expression of BMPs and BMP signaling components has only been partially examined at the cellular level.
Yan Yiu, Yu +5 more
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To BMP or not to BMP during vertebrate limb bud development
Seminars in Cell & Developmental Biology, 2014The analysis of vertebrate limb bud development provides insight of general relevance into the signaling networks that underlie the controlled proliferative expansion of large populations of mesenchymal progenitors, cell fate determination and initiation of differentiation.
Pignatti, Emanuele +2 more
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Orthopaedic Nursing, 2005
Bone morphogenetic proteins (BMP) are being increasingly used in orthopaedic surgery. These small molecules are capable of inducing bone formation when delivered in the appropriate concentration and on the appropriate scaffold. Not all BMPs are equally effective, and there are currently only two Food and Drug Administration (FDA)-approved "on-label ...
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Bone morphogenetic proteins (BMP) are being increasingly used in orthopaedic surgery. These small molecules are capable of inducing bone formation when delivered in the appropriate concentration and on the appropriate scaffold. Not all BMPs are equally effective, and there are currently only two Food and Drug Administration (FDA)-approved "on-label ...
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BMP PERFORMANCE COMPARISONS: EXAMPLES FROM THE INTERNATIONAL STORMWATER BMP DATABASE
Proceedings of the Water Environment Federation, 2005This paper explores the relative pollutant removal performance of several BMPs using data contained in the International Stormwater BMP Database. These BMPs include retention ponds, extended detention basins, vegetated swales, and sand filters. While the Database contains numerous studies with varying amounts of detail, this comparison is based on the ...
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