Results 1 to 10 of about 132,478 (140)

Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates [PDF]

Signal Transduction and Targeted Therapy
Transforming growth factor beta (TGFβ) plays a crucial role in pancreatic ductal adenocarcinoma (PDAC) progression by promoting immune suppression, fibrosis, and metastasis. Given its central role in shaping the tumor microenvironment, TGFβ has attracted
Josephine Hallundbæk Ruders, Shamaila Munir Ahmad, Rasmus Erik Johansson Mortensen, Özcan Met, Mikkel Byrdal, Inna Markovna Chen, Susann Theile, Morten Orebo Holmström, Mads Hald Andersen   +8 more
doaj   +2 more sources

Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells. [PDF]

PLoS ONE, 2013
Transforming growth factor-beta (TGFβ) is a secreted polypeptide that plays essential roles in cellular development and homeostasis. Although mechanisms of TGFβ-induced responses have been characterized, our understanding of TGFβ signaling remains ...
Isabelle Pot, Shachi Patel, Lili Deng, Amrita Singh Chandhoke, Chi Zhang, Azad Bonni, Shirin Bonni   +6 more
doaj   +5 more sources

Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]

, 2012
Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina, Carol A. Feghali-Bostwick, Joseph M. Pilewski, Logan R. Mlakar, Sebastien Fuchs, Ximena D. Ruiz, Yukie Yamaguchi, Yunyun Su   +7 more
core   +16 more sources

Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney

Disease Models & Mechanisms, 2021
Glomerulosclerosis and tubulointerstitial fibrosis are pathological features of chronic kidney disease. Transforming growth factor β (TGFβ) is a key player in the development of fibrosis.
Elia Escasany, Borja Lanzón, Almudena García-Carrasco, Adriana Izquierdo-Lahuerta, Lucía Torres, Patricia Corrales, Ana Elena Rodríguez Rodríguez, Sergio Luis-Lima, Concepción Martínez Álvarez, Francisco Javier Ruperez, Manuel Ros, Esteban Porrini, Mikael Rydén, Gema Medina-Gómez   +13 more
doaj   +1 more source

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]

, 2020
The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez, A Woods, AR Ramjaun, AY Hsing, B Bierie, B Ozdamar, B-C Kim, BR Binder, C Allan, CJ David, CS Hill, DB Shackelford, EC Connolly, FA Ran, G Avery-Cooper, G Rena, G Rosti, GD Cuny, GJ Inman, GJ Inman, GM Keating, H Ikushima, J Massagué, J Massagué, J Massaous, J Ozanne, J Song, J Vogt, J Xu, JF Callahan, JL Wrana, JM Lizcano, Joan Massagué, JY Altarejos, K Clark, KA Brown, KJ Livak, LC Spender, LC Spender, M Abe, M Kowanetz, M Tojo, MO Li, MR Keeton, NJ Bright, P Lönn, PH Lin, PK Datta, PM Siegel, RJ Akhurst, RJ Akhurst, S DaCosta Byfield, S Dennler, S Edlund, S Strickson, SA Hawley, T Sonntag, TB Sundberg, Y Drabsch, Y Liu, Y Shi, Y Yang, Y Zhang, Y Zhang   +63 more
core   +2 more sources

Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders

Cell Stress, 2020
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs.
Christian Hiepen, Jerome Jatzlau, Petra Knaus   +2 more
doaj   +1 more source

USP11 augments TGFβ signalling by deubiquitylating ALK5 [PDF]

Open Biology, 2012
Summary The TGFβ receptors signal through phosphorylation and nuclear translocation of SMAD2/3. SMAD7, a transcriptional target of TGFβ signals, negatively regulates the TGFβ pathway by recruiting E3 ubiquitin ligases and targeting TGFβ receptors for ...
Mazin A. Al-Salihi, Lina Herhaus, Thomas Macartney, Gopal P. Sapkota   +3 more
doaj   +1 more source

Tgfβ signaling is required for tenocyte recruitment and functional neonatal tendon regeneration

eLife, 2020
Tendon injuries are common with poor healing potential. The paucity of therapies for tendon injuries is due to our limited understanding of the cells and molecular pathways that drive tendon regeneration.
Deepak A Kaji, Kristen L Howell, Zerina Balic, Dirk Hubmacher, Alice H Huang   +4 more
doaj   +1 more source

Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfa

OncoImmunology, 2021
Most monoclonal antibodies (MAbs), including immune checkpoint inhibitor MAbs, are delivered intravenously (i.v.) to patients. Recent clinical studies have demonstrated that some anti-PD1 MAbs may also be delivered subcutaneously (s.c.), with clinical ...
Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom, Sofia R. Gameiro   +5 more
doaj   +1 more source

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism [PDF]

Open Biology, 2018
The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children.
Max D. Knickmeyer, Juan L. Mateo, Priska Eckert, Eleni Roussa, Belal Rahhal, Aimee Zuniga, Kerstin Krieglstein, Joachim Wittbrodt, Stephan Heermann   +8 more
doaj   +1 more source