Results 31 to 40 of about 132,620 (281)

WWP2 ubiquitin ligase and its isoforms: New biological insight and promising disease targets [PDF]

, 2011
A number of recent papers on the WWP2 E3 ubiquitin ligase and two novel WWP2 isoforms have revealed important biological insight and disease-specific functions, and also impacted on our understanding of ubiquitin ligases in cell cycle regulation ...
Chantry, A
core   +1 more source

TGFβ (transforming growth factor-β) blockade induces a human-like disease in a nondissecting mouse model of abdominal aortic aneurysm [PDF]

, 2017
Objective-Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGF beta (transforming growth factor-beta) activity-a guardian of vascular integrity ...
Clément, Marc, Esposito, Bruno, Finigan, Alison, Lareyre, Fabien, Mallat, Ziad, Master, Leanne, Patel, Meghana, Pohlod, Stefanie, Raffort, Juliette, Stergiopulos, Nikolaos, Taleb, Soraya, Trachet, Bram, Vandestienne, Marie   +12 more
core   +2 more sources

Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways via off-VEGF signaling

Cancer Biology & Medicine, 2020
Objective: Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor (VEGF) with clear clinical benefits.
Xiaoling Zhang, Yan Zhang, Yanan Jia, Tingting Qin, Cuicui Zhang, Yueya Li, Chengmou Huang, Zhujun Liu, Jing Wang, Kai Li   +9 more
doaj   +1 more source

Transforming growth factor-beta targets Formin-like 2 for Angiopoietin-like 4 secretion during the epithelial mesenchymal transition [PDF]

, 2019
Epithelial to Mesenchymal transition (EMT) is a highly dynamic process that plays a crucial role in tumor progression and metastasis. While remodelling of the actin cytoskeleton is a hallmark of EMT, the responsible actin regulating factors are less well
Moussi, Christel Jessica
core   +1 more source

Potentiating tumor immunity using aptamer-targeted RNAi to render CD8+ T cells resistant to TGFβ inhibition

OncoImmunology, 2018
TGFβ secreted by tumor cells and/or tumor infiltrating stromal cells is a key mediator of tumor growth and immune suppression at the tumor site. Nonetheless, clinical trials in cancer patients targeting the TGFβ pathway exhibited at best a modest ...
Yvonne Puplampu-Dove, Tal Gefen, Anugraha Rajagopalan, Darija Muheramagic, Brett Schrand, Eli Gilboa   +5 more
doaj   +1 more source

Inhibition of transforming growth factor-β in osteoarthritis. Discrepancy with reduced TGFβ signaling in normal joints

Osteoarthritis and Cartilage Open, 2022
Objective: Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is central in the regulation of joint health and disease. Inhibition of TGFβ activity/signaling in experimental osteoarthritis (OA) has been performed to modulate OA severity ...
Peter M. van der Kraan
doaj   +1 more source

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition [PDF]

, 2016
The transcription factor Snail is a master regulator of cellular identity and epithelial-to-mesenchymal transition (EMT) directly repressing a broad repertoire of epithelial genes.
A Kuzmichev, A Tramontano, AM Khalil, C Battistelli, C Battistelli, C Chu, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cicchini, C Cifuentes-Rojas, C Davidovich, CA McHugh, CL Tien, E Bolotin, F Garibaldi, F J Gonzalez, G Deb, G Grassi, H Peinado, H Peinado, J Chen, J Yang, J Zhao, JA Simon, JL Rinn, JP Thiery, KD Nolan, L Amicone, L Amicone, L Grassi, L Li, L Santangelo, L Santangelo, M Colletti, M Courel, M Kretz, M Rodriguez, M Tripodi, M Yu, MA Nieto, MA Perez-Moreno, MC Tsai, OG McDonald, P Arnold, P Wongtrakoongate, Q Cao, R Cao, R Kogo, RA Gupta, RY Huang, S Fujii, S Javaid, S Kaneko, S Lamouille, TD Schmittgen, V de Nonno, Y Chen, Y Lin, Y Nie, Y Yonemitsu, YJ Geng, Z Hou, Z Yang, ZT Tong   +65 more
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Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

OncoImmunology, 2020
TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor promoting properties, depending on tissue and cellular context. Emerging data support a role for TGFβ in suppression of antitumor immunity.
Rita Greco, Hongjing Qu, Hui Qu, Joachim Theilhaber, Gary Shapiro, Richard Gregory, Christopher Winter, Natalia Malkova, Frank Sun, Julie Jaworski, Annie Best, Lily Pao, Andrew Hebert, Mikhail Levit, Alexei Protopopov, Jack Pollard, Keith Bahjat, Dmitri Wiederschain, Sharad Sharma   +18 more
doaj   +1 more source

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]

, 2015
TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O, Dunbar, Donald R, Harrison, David J, Prost, Sandrine, Sheahan, Sharon   +4 more
core   +1 more source