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Clinical Application of the BMPs
The Journal of Bone and Joint Surgery-American Volume, 2001It has been almost 40 years since Marshall Urist’s seminal observations on the bone induction principle were first published, yet we have not seen the common use of bone morphogenetic proteins (BMPs) in our patients. I believe that two obstacles have delayed this translation: (1) underestimation of the need for a higher concentration or dose of BMPS in
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BMPs and the muscle–bone connection
Bone, 2015Muscle and bone are two intimately connected tissues. A coordinated interplay between these tissues at mechanical levels is required for their development, function and ageing. Evidence is emerging that several genes and molecular pathways exert a pleiotropic effect on both muscle and bone. Bone morphogenetic proteins (BMPs) are secreted signal factors
Sartori R., Sandri M.
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2017
Bone morphogenetic proteins are regulators of embryonic development with multiple functions in adult organs and tissues. Here we summarize effects of BMPs outside the musculoskeletal system, focused on their role in inflammatory disorders, e.g., fibrosis, inflammatory bowel disease, anchylosing spondylitis, and rheumatoid arthritis.
Grgurević, Lovorka +2 more
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Bone morphogenetic proteins are regulators of embryonic development with multiple functions in adult organs and tissues. Here we summarize effects of BMPs outside the musculoskeletal system, focused on their role in inflammatory disorders, e.g., fibrosis, inflammatory bowel disease, anchylosing spondylitis, and rheumatoid arthritis.
Grgurević, Lovorka +2 more
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Clinical calcium, 2004
Bone morphogenetic proteins (BMP) are cytokines that promote differentiation of mesenchymal stem cells into differentiated osteoblasts and bone formation. Recently, HMG-CoA reductase inhibitors (statins) emerged as a candidate for the treatment of osteoporosis, because they stimulate BMP-2 expression and bone formation.
Keizo, Ohnaka, Ryoichi, Takayanagi
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Bone morphogenetic proteins (BMP) are cytokines that promote differentiation of mesenchymal stem cells into differentiated osteoblasts and bone formation. Recently, HMG-CoA reductase inhibitors (statins) emerged as a candidate for the treatment of osteoporosis, because they stimulate BMP-2 expression and bone formation.
Keizo, Ohnaka, Ryoichi, Takayanagi
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Clinical calcium, 2006
Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the ...
Midori, Nakamura +3 more
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Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the ...
Midori, Nakamura +3 more
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Human osteophytes produce BMP-3 & BMP-7
Bone (New York, N.Y.), 1999Osteophytes are newly formed osseous and cartilaginous tissue outgrowths forming mostly at the margin of osteoarthrotic joints. They are extremely variable and irregular in size and shape but it seems that they develope and growth by the same processes of intramembranous and endochondral ossification as bones in embryonal development.
Zoričić Cvek, Sanja +3 more
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2015
Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta super family. These growth molecules, originally associated with bone and cartilage development, are now known to play important roles in morphogenesis and homeostasis in many other tissues. Recently, significant contributions of
Wei, Xiong, Li, Wang, Fenglei, Yu
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Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta super family. These growth molecules, originally associated with bone and cartilage development, are now known to play important roles in morphogenesis and homeostasis in many other tissues. Recently, significant contributions of
Wei, Xiong, Li, Wang, Fenglei, Yu
openaire +1 more source