Results 121 to 130 of about 905,740 (294)

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator

eLife
BMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in anthozoan cnidarians. So far, cnidarian studies have focused on the role of different BMP signaling network components in regulating ...
Paul Knabl, Alexandra Schauer, Autumn P Pomreinke, Bob Zimmermann, Katherine W Rogers, Daniel Čapek, Patrick Müller, Grigory Genikhovich   +7 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.

PLoS Biology, 2018
The neural crest is induced at the neural plate border during gastrulation by combined bone morphogenetic protein (BMP), fibroblast growth factor (FGF), and Wnt signaling.
Michael L Piacentino, Marianne E Bronner
doaj   +1 more source

Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury [PDF]

, 2006
Peer ...
O'Dowd, John, De Bari, C, De Bari, Cosimo, Barone, Francesca; id_orcid, Pitzalis, Costantino, Dell'Accio, Francesco, El Tawil, Noha M F, Barone, Francesca, Mitsiadis, TA, Mitsiadis, Thimios A, Dell'Accio, F, Pitzalis, C, El Tawil, N M F, Barone, F, El Tawil, NMF, O'Dowd, J, Mitsiadis, T A, Mitsiadis TA, De Bari C, Dell’Accio F, O’Dowd J, Pitzalis C, Barone F, El Tawil NM   +23 more
core   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

A Wnt-Bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis

, 2012
Many vertebrate organs form through the sequential and reciprocal exchange of signaling molecules between juxtaposed epithelial and mesenchymal tissues.
Koo, Samuel, Maas, Richard L., O'Connell, Daniel J., O'Connell, Joyce T., Haseley, Psalm S., Kamiya, Nobuhiro, Mammoto, Tadanori, Ingber, Donald E., Ho, Joshua W.K., Park, Peter J., Turbe-Doan, Annick   +10 more
core   +1 more source

BMP-9 Modulates the Hepatic Responses to LPS

, 2020
It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under conditions of ...
Carolin Mogler, Teufel, Andreas, Andreas Teufel, Claus Hellerbrand, Matthias P. A. Ebert, Hellerbrand, Claus, Rahbari, Nuh, König, Courtney, Katja Breitkopf-Heinlein, Breitkopf-Heinlein, Katja, Haristi Gaitantzi, Tatjana Seitz, Augustin, Hellmut G., Chen Cai, Vanessa Rausch, de la Torre, Carolina, Gretz, Norbert, Ebert, Matthias P. A., Birgin, Emrullah, Karch, Julius, Rausch, Vanessa, Seitz, Tatjana, Cai, Chen, Germann, Lena, Julius Karch, Mogler, Carolin, Nuh Rahbari, Norbert Gretz, Emrullah Birgin, Courtney König, Gaitantzi, Haristi, Lena Germann, Hellmut G. Augustin, Carolina de la Torre, Timo Itzel, Itzel, Timo   +35 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source