Results 101 to 110 of about 115,318 (308)

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

International Journal of Biological Sciences, 2012
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is involved in a vast majority of cellular processes and is fundamentally important throughout life.
Guiqian Chen, Chuxia Deng, Yi-Ping Li
doaj  

Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish

eLife, 2020
Fibrodysplasia ossificans progressiva (FOP) is a rare human genetic disorder characterized by altered skeletal development and extraskeletal ossification.
Robyn S Allen, Benjamin Tajer, Eileen M Shore, Mary C Mullins   +3 more
doaj   +1 more source

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]

, 2013
Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor, Amthor, Ball, Bayat, Bianca C. Bernardo, Bodine, Bogdanovich, Bradley J. Turner, Catherine E. Winbanks, Chung, Claudia Beyer, Clever, Cohen, Craig A. Harrison, Donaldson, Dworkin, Dworkin, Fischle, Gregorevic, Grönroos, Gurney, Hayashi, Heitman, Holley, Hongwei Qian, Ibebunjo, Imamura, Ishida, Julie R. McMullen, Justin L. Chen, Kalista, Kambadur, Katagiri, Kevin I. Watt, Langenfeld, Lars Larsson, Latres, Lee, Lee, Lee, Massagué, Mathews, McCabe, McPherron, Moresi, Musarò, Nakao, Nickel, Ochala, Paul Gregorevic, Pescatori, Potthoff, Pourquié, Rachel E. Thomson, Rafael, Rebbapragada, Rommel, Ruschke, Sako, Sandri, Sartori, Sartori, Sean L. McGee, Shioi, Stitt, Suryawan, Tang, Timothy Connor, Townsend, Trendelenburg, Winbanks, Winbanks, Yamamoto, Yingying Liu, Zhou, Zimmerman   +75 more
core   +2 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b.

PLoS Genetics, 2019
During vertebrate early embryogenesis, the ventral development is directed by the ventral-to-dorsal activity gradient of the bone morphogenetic protein (BMP) signaling.
Ding Ye, Xiaosi Wang, Changyong Wei, Mudan He, Houpeng Wang, Yanwu Wang, Zuoyan Zhu, Yonghua Sun   +7 more
doaj   +1 more source

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model

Disease Models & Mechanisms, 2017
The S113R mutation (c.339T>G) (MIM #603690.0001) in SLC33A1 (MIM #603690), an ER membrane acetyl-CoA transporter, has been previously identified in individuals with hereditary spastic paraplegia type 42 (SPG42; MIM #612539).
Pingting Liu, Baichun Jiang, Jian Ma, Pengfei Lin, Yinshuai Zhang, Changshun Shao, Wenjie Sun, Yaoqin Gong   +7 more
doaj   +1 more source

The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease

Scientific Reports, 2020
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear.
Timothy E. Thayer, Christian L. Lino Cardenas, Trejeeve Martyn, Christopher J. Nicholson, Lisa Traeger, Florian Wunderer, Charles Slocum, Haakon Sigurslid, Hannah R. Shakartzi, Caitlin O’Rourke, Georgia Shelton, Mary D. Buswell, Hanna Barnes, Leif R. Neitzel, Clara D. Ledsky, Jason Pingcheng Li, Megan F. Burke, Eric Farber-Eger, Daniel S. Perrien, Ravindra Kumar, Kathleen E. Corey, Quinn S. Wells, Kenneth D. Bloch, Charles C. Hong, Donald B. Bloch, Rajeev Malhotra   +25 more
doaj   +1 more source