Results 91 to 100 of about 905,740 (294)
Advanced Science, EarlyView.NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen +7 more
wiley +1 more source
Intriguing Extracellular Regulation of BMP Signaling [PDF]
Developmental Cell, 2008 Extracellular components of the BMP signaling pathway bind specific partners with high affinity, implying regulation by dedicated protein-protein interactions. In this and other recent issues of Developmental Cell, new results by Ambrosio et al. (and others) suggest, however, that these factors interact in more complex ways to regulate BMP signaling on
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Molecules, 2015 Bone morphogenetic proteins (BMPs) control many developmental and physiological processes, including skeleton formation and homeostasis. Previous studies in zebrafish revealed the crucial importance of proper BMP signaling before 48 h post-fertilization (
Thomas Windhausen +3 more
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RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish. [PDF]
PLoS ONE, 2012 The cartilaginous elements forming the pharyngeal arches of the zebrafish derive from cranial neural crest cells. Their proper differentiation and patterning are regulated by reciprocal interactions between neural crest cells and surrounding endodermal ...
Julia Dalcq +6 more
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Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
Nephronectin regulates cardiac valve development via BMP4-HAS2 signaling in zebrafish [PDF]
, 2011 It has been estimated that about 1% of live births carry severe congenital heart defects and 20-30% among them have valve malformations. Despite its medical importance the underlying cause of many valvular diseases remains undiscovered.
Patra, Chinmoy (Dr.)
core
The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
, 2019 The Transforming Growth Factor beta (TGFβ) and Bone Morphogenic Protein (BMP) pathways intersect at multiple signaling hubs and cooperatively or counteractively participate to bring about cellular processes which are critical not only for tissue ...
Carla Cossu +3 more
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Advanced Science, EarlyView.The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan +10 more
wiley +1 more source
Advanced Science, EarlyView.A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang +7 more
wiley +1 more source
BMP signaling and stem cell regulation
Developmental Biology, 2005 Stem cells play an essential role in cellular specialization and pattern formation during embryogenesis and in tissue regeneration in adults. This is mainly due to a stem cell's ability to replenish itself (self-renewal) and, at the same time, produce differentiated progeny. Realization of these special stem cell features has changed the prospective of
Zhang, Jiwang, Li, Linheng
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