Results 111 to 120 of about 27,097 (262)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Precision Oncology via Radiotherapy‐Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation

Advanced Science, EarlyView.
This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang, Tanfeng Zhang, Junliang Dong, Wenjing Sun   +3 more
wiley   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Holographic Photopolymerizable Glass: Enhancing Exposure Sensitivity by Tailoring Photoinitiating Systems Based on BODIPY Dyes

Advanced Photonics Research
The photoinitiating system (PIS) is a key component of holographic materials which needs to be carefully selected and optimized to achieve efficient photopolymerization and, as a result, highly efficient holographic structures.
Tatsiana Mikulchyk, Aimee Sheehan, Metodej Dvoracek, Izabela Naydenova, Mikhail A. Filatov   +4 more
doaj   +1 more source

Stabilization of PUFA‐Rich Mayonnaise Against Lipid Oxidation: A Review of the Last Three Decades of Research

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Mayonnaise, a widely consumed oil‐in‐water emulsion, is highly susceptible to lipid oxidation due to its high content of polyunsaturated fatty acids (PUFAs) and the presence of pro‐oxidant factors such as low pH and iron from egg yolk. Over the past three decades, extensive research has focused on understanding oxidation mechanisms, analytical
Sakhi Ghelichi, Betül Yesiltas, Charlotte Jacobsen   +2 more
wiley   +1 more source

Synthesis and Optical Properties of Diboron Complexes of 1,4‐Anthraquinone Derivatives

Chemistry – A European Journal, EarlyView.
1,4‐Diboron complexes exhibit near‐infrared fluorescence, in contrast to non‐emissive 1,5‐diboron analogues. Fluorescence quantum yields decrease with increasing electron‐donating substituents, attributed to enhanced nonradiative decay via intramolecular PeT.
Yasuhiro Kubota, Ayumi Ogasawara, Ayato Hakamada, Naoya Suzuki, Masayasu Taki, Shota Mizuno, Toshiyasu Inuzuka, Kazumasa Funabiki, Chie Yamada‐Kubota, Miho Kuwahara, Tetsuya Hara   +10 more
wiley   +1 more source

Single‐Step Synthesis of Dithieno[3,2‐b:2′,3′‐e]Pyridines and Their Acid‐Dependent Optical and Photosensitising Properties

Chemistry – A European Journal, EarlyView.
The synthesis of dithieno[3,2‐b:2′,3′‐e]pyridines (DTPs) is herein reported, and their optical properties are studied both experimentally and computationally. Protonation or methylation of the nitrogen atom induced bathochromic shifts in their absorption and emission spectra.
Dominic Taylor, Matthew Wallace, Leonardo Amicosante, Gary S. Nichol, Scott J. Dalgarno, Filipe Vilela, Iain A. Wright, Neil B. McKeown   +7 more
wiley   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source

Ratiometric pH‐Responsive and Biomimetic Microparticles for Quantitative Monitoring of Phagosomal Acidification

Chemistry – A European Journal, EarlyView.
A series of hydrosoluble BODIPY pH probes allows building biomimetic pH sensors based on micrometric oil‐in‐water droplets. The ratiometric fluorescence output offers quantitative information on the evolution of pH during phagosome maturation. ABSTRACT We present a modular biomimetic fluorescent sensing platform designed to precisely interrogate the ...
Sophie Michelis, Héloïse Uhl, Florence Niedergang, Jacques Fattaccioli, Blaise Dumat, Jean‐Maurice Mallet   +5 more
wiley   +1 more source

An Electrophilic Uridine Building Block for Post‐Synthetic RNA Modification as Exemplified for Spin Labeling

Chemistry – A European Journal, EarlyView.
An electrophilic 5‐isothiocyanatomethyl uridine building block enables modular post‐synthetic RNA labeling with primary amine‐containing probes. Positioning the functionality in the major groove minimizes structural perturbation and allows facile conjugation of sensitive tags such as TEMPO spin labels for paramagnetic relaxation enhancement studies ...
Lisa Ruetz, Sonja Leiner, Alessandro Marotto, Raphael Plangger, Christoph Kreutz   +4 more
wiley   +1 more source