Results 121 to 130 of about 4,583,317 (294)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Drought-linked resource limitations on the body condition of a large ungulate
Frontiers in Ecology and EvolutionUnderstanding how indirect effects of climate can interact with density-dependent processes has become increasingly important as variability changes resource availability for wildlife. Both climate and animal density can drive the abundance of vegetation
Casey L. Brown +6 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
The gut microbiota-immune-brain axis in a wild vertebrate: dynamic interactions and health impacts
Frontiers in MicrobiologyThe gut microbiota-immune-brain axis is a feedback network which influences diverse physiological processes and plays a pivotal role in overall health and wellbeing. Although research in humans and laboratory mice has shed light into the associations and
Hugo Pereira +19 more
doaj +1 more source
Body Condition Scoring for Horses
, 2019 Horse enthusiasts are often concerned about their horse’s health, appearance and performance. A major key to accomplishing these three goals is to keep your horse at a desirable body condition, or degree of fat cover. However, being able to accurately evaluate a horse to tell if they are over or underweight has been a subjective practice for many years.
Hoopes, Karl +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Body condition index in breeding black iguana females (Ctenosaura pectinata) in captivity
Revista de la Facultad de Ciencias Agrarias, 2020 The body condition index is a measure that attempts to describe energy storage compared to body length. This research was carried out with the aim of obtaining a body condition index in Ctenosaura pectinata.
José Luis Arcos-García +5 more
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