Results 131 to 140 of about 1,389,452 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Canine neonatal clinical evaluation through Apgar score and body temperature under distinct whelping condition [PDF]
Em medicina veterinária, a mortalidade neonatal nas primeiras semanas de vida alcança percentuais próximos a 30%. A inabilidade em proceder a correta análise clínica e o déficit no conhecimento técnico-científico são os principais responsáveis pelos ...
LÚCIO, Cristina de Fátima +4 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Performance and feed intake of five beef suckler cow genotypes and pre-weaning growth of their progeny [PDF]
, 2008 peer-reviewedThe effect of beef suckler cow genotype on feed intake, performance, milk yield and on pre-weaning growth of their progeny was determined over four lactations.
Drennan, Michael J +3 more
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NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Животновъдни науки, 2011 The study was carrying out with 32 cows, of which 17 Holstein and 15 Brown Swiss ones at the farm of the Agricultural Institute Stara Zagora. Cows from both breeds are reared together with the same technology and nutrition.
ЖИВКА ГЕРГОВСКА +4 more
doaj
AnimalsUnder climate change, animal breeding faces severe nutritional challenges, exhibiting their resilience and efficiency to survive and produce. The animals’ robustness can be evaluated through the use and reconstitution of body reserves (BR).
Yathreb Yagoubi +6 more
doaj +1 more source
Evaluation of the use of milk urea nitrogen (MUN) as an indicator of nutritional status of dairy cattle in smallholder farms in Kiambu district [PDF]
, 2010 A survey was conducted to evaluate the use of Milk Urea Nitrogen as an indicator of nutrition status of lactating animals. Twenty-seven animals in a randomly selected sample of 21 farms in Kiambu District were monitored for nutritional status for 12 ...
Gachuiri, C. +4 more
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Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source