Results 101 to 110 of about 847,290 (339)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

“A Cloud of Constitutional Illegitimacy”: Prospectivity and the De Facto Doctrine in the Gerrymandering Context [PDF]

, 2020
Courts have traditionally shielded the acts of malapportioned or otherwise illegally constituted legislatures from dissolution by employing the “de facto doctrine,” an ancient common law policy tool with medieval roots.
Scheidt, Spencer
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Constitution View Of The Person

Aufklärung, 2015
According to the Constitution View (CV), the person is not identical to his body or even to his psychological states. What makes a Person1 at t1 the same Person2 at t2 is his first-person perspective (FPP). The person would be then constituted by one
Wellistony Carvalho Viana
doaj   +1 more source

Book Review [PDF]

, 2006
Reviewing Deborah Z. Cass, The Constitutionalization of the World Trade Organization: Legitimacy, Democracy, and Community in the International Trading System (Oxford University Press ...
Pauwelyn, Joost H. B.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A comprehensive study of psychological well-being and traditional Chinese medicine constitutions among model workers in Beijing

Frontiers in Psychiatry
BackgroundBody constitution is the foundation of Traditional Chinese Medicine (TCM), and model workers consist of a special group of workers within China.
Hongli Cao, Xianyang Chen, Yige Song, Shawn Xiang Li, Hui Ma, Guosheng Zhang, Tianyu Gong, Hong Yu, Zijin Liu   +8 more
doaj   +1 more source

Living a corporate lifestyle: The application of 'body corporate' under Islamic institutions in Malaysia [PDF]

, 2009
Businesses are not alien to Islam for it has been the practice of Prophet Muhammad p.b.u.h. The Holy Prophet himself was a successful trader. In Islam, particularly the Arab countries, they refer the entity carrying out the businesses and commercials as
Ayub, Zainal Amin, Azrae, Ahmad Nasyran, Mohamed Yusoff, Zuryati   +2 more
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A CROSS-SECTIONAL STUDY ON BODY CONSTITUTION (DHEGA ILAKKANAM) IN UTHIRAVATHA SURONITHAM (RHEUMATOID ARTHRITIS)

, 2021
S Mahespriya, H. Vetha Merlin Kumari, Nalini Sofia H, T Lakshmi Kantham, Rita Kumari   +4 more
openalex   +1 more source