Results 101 to 110 of about 849,385 (303)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Constitution View Of The Person
Aufklärung, 2015 According to the Constitution View (CV), the person is not identical to his body or even to his psychological states. What makes a Person1 at t1 the same Person2 at t2 is his first-person perspective (FPP). The person would be then constituted by one
Wellistony Carvalho Viana
doaj +1 more source
Dress and age: the intersection of life and work [PDF]
, 2015 In this article I outline the influences, intellectual and personal, that have led me to the subject of dress and age, a topic that I have explored with great enjoyment over the last decade.
Twigg, Julia
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Frontiers in PsychiatryBackgroundBody constitution is the foundation of Traditional Chinese Medicine (TCM), and model workers consist of a special group of workers within China.
Hongli Cao +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The problem of authority and the proposal for an Indigenous advisory body [PDF]
INTRODUCTION: Proposals for the establishment of an Indigenous advisory body within the Australian Constitution are genuinely innovative and exciting. Designing such a body is a challenge.
Fergal Davis
core
Legislative Delegation and Two Conceptions of the Legislative Power [PDF]
, 2006 [Excerpt] The current federal government, with its burgeoning administrative agencies, does not embody what most Americans would recognize as the constitutional doctrine of separation of powers.
Sarvis, Robert C.
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source