Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou+8 more
wiley +1 more source
The influence of gender and waist circumference in the association of body fat with cardiometabolic diseases. [PDF]
Bagheri M+4 more
europepmc +1 more source
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang+8 more
wiley +1 more source
Childhood Body Fat Patterns and Obesity Prevalence in Kazakhstan. [PDF]
Abdrakhmanova S+8 more
europepmc +1 more source
STUDY ON EFFECTS OF ENDOCRINES ON INCREASE IN AMOUNT OF BODY FAT
YUJI SUEYOSHI, Akihiko Kato
openalex +2 more sources
The Morphological, Behavioral, and Transcriptomic Life Cycle of Anthrobots
DNA is thought to determine shape, behavior, and lifespan, with developmental plasticity reserved for stem cells, embryos, and species like amphibia. How much morphogenetic plasticity do adult somatic human cells exhibit? Anthrobots are a self‐organizing, motile synthetic living construct made of genetically normal human epithelial cells.
Gizem Gumuskaya+6 more
wiley +1 more source
Agreement between equation-derived body fat estimator and bioelectrical impedance analysis for body fat measurement in middle-aged southern Indians. [PDF]
Endukuru CK+4 more
europepmc +1 more source
Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment
A novel orally drug‐probiotic co‐delivery system designated as Rh‐YBS for UC treatment, which highlights three innovations: (i) YPs involves colonic submucosa delivery via M cells; (ii) Rh (drug) promotes the colonization and growth of BS (probiotic) in the colon.
Lingqiang Li+21 more
wiley +1 more source
Body Fat and Visceral Fat Values in Spanish Healthcare Workers: Associated Variables. [PDF]
Tárraga Marcos PJ+6 more
europepmc +1 more source