Results 91 to 100 of about 288,170 (305)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Persistence of Zika Virus in Body Fluids — Final Report [PDF]

, 2019
Zika Virus; Body FluidsVirus Zika; Fluids corporalsFluidos corporalesPaz-Bailey and colleagues (Sept. 27 issue)1 describe the dynamics of Zika virus (ZIKV) in body fluids in a cohort of participants who lived in an area where the virus was endemic and in
Molina Romero, Israel, Salvador Velez, Fernando M, Sánchez Montalvá, Adrián   +2 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

ASSESSMENT OF DIFFERENT MODES OF TRANSMISSION OF HIV IN PATIENTS WITH HIV/AIDS

Gomal Journal of Medical Sciences, 2015
Background: HIV infection can be transmitted via a variety of ways. The objectives of this study were to determine the frequency distribution of gender, age grouping, marital status, and mode of transmission in HIV/AIDS patients.
Nafisa Batool Tahir, Mohammad Mehran Shah, Qazi Tahir Uddin   +2 more
doaj  

Body Fluids and Fluid Bodies: Trans-Corporeal Connections in Contemporary German Narratives of Illness

Humanities, 2019
Medicine uses body fluids for the construction of medical knowledge in the laboratory and at the same time considers them as potentially infectious or dirty.
Katja Herges
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Adverse incidents resulting in exposure to body fluids at a UK dental teaching hospital over a 6-year period

, 2012
A Hughes,1 L Davies,1 R Hale,1 JE Gallagher21Kings College Hospital NHS Foundation Trust, 2King's College London Dental Institute, London, United KingdomBackground: The safety and protection of patients and health care workers is of paramount ...
Gallagher JE, Hale R, Davies L, Hughes A
core  

Effects of nano-biphasic calcium phosphate composite on bioactivity and osteoblast cell behavior in tissue engineering applications

Journal of Medical Signals and Sensors, 2016
In this paper, preparation, bioactivity, and osteoblast cell behavior of cortical bone derived nano-biphasic calcium phosphate (nano-BCP) are presented.
Mehdi Ebrahimian-Hosseinabadi, Mohammadreza Etemadifar, Fakhredin Ashrafizadeh   +2 more
doaj  

Aggregation‐induced emission luminogens in in vitro diagnostics: Advancing biomarker detection in body fluids

Interdisciplinary Medicine
Rapid, sensitive, and accurate detection of ingredients in body fluids is crucial for monitoring health status and diagnosing diseases. Fluorescent biosensors have emerged as a user‐friendly tool for biomarker detection, because of their high sensitivity,
Qi Liu, Xirui Chen, Kenian Wang, Yifan Wu, Xiangcai Zou, Ying Li   +5 more
doaj   +1 more source