Results 71 to 80 of about 682,566 (296)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Human urinary metabolomics as biomarkers in tobacco users: A systematic review

Contemporary Clinical Dentistry
Aim: Urine as a biofluid has been rarely used as a diagnostic fluid in oral diseases. The article aims to systematically review the utility of human urinary carcinogen metabolites as an approach for obtaining important information about tobacco and ...
Somya Sharma, Shalu Rai, Deepankar Misra, Akansha Misra, Shalini Sharma, Anusuya Sharma, Manish Singh Prayasi   +6 more
doaj   +1 more source

A Liquid Model Analogue for Black Hole Thermodynamics [PDF]

, 1996
We are able to characterize a 2--dimensional classical fluid sharing some of the same thermodynamic state functions as the Schwarzschild black hole. This phenomenological correspondence between black holes and fluids is established by means of the model ...
A. Ishihara, A. O. Barvinsky, D. Hochberg, D. J. E. Callaway, David Hochberg, G. W. Gibbons, G. ’t Hooft, J. A. Wheeler, J. A. Wheeler, J. D. Brown, J. Pérez-Mercader, J. W. York, Jr., J. W. York, Jr., J. W. York, Jr., Juan Pérez-Mercader, N. H. March, V. Frolov, W. G. Unruh, W. H. Zurek   +18 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Life at high Deborah number

, 2009
In many biological systems, microorganisms swim through complex polymeric fluids, and usually deform the medium at a rate faster than the inverse fluid relaxation time.
Berg H. C., Bird R. B., Bird R. B., Bray D., E. Lauga, Happel J., Kim S., Kiorboe T., Larson R. G., Litt M., Meyer F. A., Raz O., Tam P. Y., Tanner R. I., Wolf D. P., Wolf D. P., Wolf D. P.   +16 more
core   +1 more source

Impact of the frequency dependence of tidal Q on the evolution of planetary systems [PDF]

, 2013
Context. Tidal dissipation in planets and in stars is one of the key physical mechanisms that drive the evolution of planetary systems. Aims. Tidal dissipation properties are intrisically linked to the internal structure and the rheology of studied ...
Auclair-Desrotour, P., Mathis, S., Poncin-Lafitte, C. Le   +2 more
core   +5 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

body fluids

Citation: 'body fluids' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09640 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
C. Crawford, C. Jarman
openaire   +2 more sources