Results 61 to 70 of about 288,170 (305)

Human urinary metabolomics as biomarkers in tobacco users: A systematic review

open access: yesContemporary Clinical Dentistry
Aim: Urine as a biofluid has been rarely used as a diagnostic fluid in oral diseases. The article aims to systematically review the utility of human urinary carcinogen metabolites as an approach for obtaining important information about tobacco and ...
Somya Sharma   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Body fluids and spectroscopic techniques in forensics: A perfect match? [PDF]

open access: yes, 2015
Human body fluids are of great interest in forensics, due to the possibility to extract their genetic information. Atthe moment, there is the need to develop a non-destructive, rapid and user-friendly method for the detection andidentification of the ...
Gregório Martins, Maria Inês   +2 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

MicroRNAs in body fluids.

open access: yes, 2015
PF = pericardial fluid*Average on all samplesMicroRNAs in body fluids.
Suvi M. Kuosmanen (701393)   +5 more
core   +1 more source

Assessment of somatic mutations in urine and plasma of Wilms tumor patients

open access: yesCancer Medicine, 2020
Tumor DNA has been detected in body fluids of cancer patients. Somatic tumor mutations are being used as biomarkers in body fluids to monitor chemotherapy response as a minimally invasive tool.
Ana Carolina Kerekes Miguez   +8 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Body fluids and salt metabolism - Part II

open access: yesItalian Journal of Pediatrics, 2010
There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between ...
Bettinelli Alberto   +7 more
doaj   +1 more source

Use of Supplemented or Human Material to Simulate PD Behavior of Antibiotics at the Target Site In Vitro

open access: yesPharmaceutics, 2020
In antimicrobial drug development, in vitro antibiotic susceptibility testing is conducted in standard growth media, such as Mueller–Hinton broth (MHB).
Alina Nussbaumer-Pröll   +1 more
doaj   +1 more source

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