Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma
Cancer Management and Research, 2021 Lei Shi, Mengheng Wang, Haiping Li, Pengtao You Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, People’s Republic of ChinaCorrespondence: Pengtao YouHubei Key Laboratory of ...
Shi L, Wang M, Li H, You P
doaj
Theoretical justification and error analysis for slender body theory with free ends
, 2019 Slender body theory is a commonly used approximation in computational models of thin fibers in viscous fluids, especially in simulating the motion of cilia or flagella in swimming microorganisms.
Mori, Yoichiro +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Body fluids and salt metabolism - Part II
Italian Journal of Pediatrics, 2010 There is a high frequency of diarrhea and vomiting in childhood. As a consequence the focus of the present review is to recognize the different body fluid compartments, to clinically assess the degree of dehydration, to know how the equilibrium between ...
Bettinelli Alberto +7 more
doaj +1 more source
Evidence of Gestational Heroin Exposure by Comparative Analysis of Fetal and Maternal Body Fluids, Tissues, and Hair in a Heroin-Related Death [PDF]
, 1998 Stefanie Iwersen +3 more
openalex +1 more source
First post-Newtonian $N$-body problem in Einstein-Cartan theory with the Weyssenhoff fluid: equations of motion [PDF]
, 2022 Emmanuele Battista, Vittorio De Falco
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Validation of forensic body fluid identification based on empirically normalized miRNA expression data [PDF]
, 2015 Eva Sauer +2 more
openalex +1 more source