Results 71 to 80 of about 1,284,905 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Comparative Analysis of Production Performance and Physiological Responses in Snowy White Chickens Reared at Different Altitudes

Life
This study evaluated variations in phenotypic and physiological traits of Snowy White chickens reared under high-altitude conditions in Lhasa, China, at 3650 m and low-altitude conditions in Ya’an, China, at 600 m. Chickens reared at high altitude showed
Mingzhu Shan, Yang Liu, Tong Li, Yingjie Wang, Gang Shu, Liuting Wu, Xiaoling Zhao   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Relationship between body weight and body measurements of Aceh cattle [PDF]

Malaysian Journal of Animal Science, 2015
Data on body weight (BW) and measurements: withers height (WH), body length (BL) and heart girth (HG) of 79 (39 males and 40 females) of Aceh cattle (average 550 days of age) were collected at the Breeding Station in Indrapuri district, Aceh Besar ...
Putra, W.P.B., Sumadi, Hartatik, T., Saumar, H.   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Predicting the level and digital achievement in terms of some body measurements of 2000-meter rowing players in qualifying for the 2023 Asian Cup Championship

التربية الرياضية
The study aimed to identify the relationship of body measurements to the level and digital achievement of 2000-meter rowing players in the 2023 Asian Cup Championship, and to identify the contribution of body measurements to the digital level of 2000 ...
Ayad Ali
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

DETERMINATION OF BODY WEIGHT AND BODY MEASUREMENTS OF AKKARAMAN SHEEP REARED AT MALYA STATE FARM IN MIDDLE ANATOLIA REGION CONDITIONS OF TURKEY

Животновъдни науки, 2014
This study was carried out to determine body weight and some body measurements of Akkaraman sheep reared at Malya state farm in Middle Anatolia region conditions of Turkey. Body weight and body measurements were measured from 60 ewes and 40 rams.
SÜLEYMAN ÇİLEK
doaj  

Measuring body composition: the limitations of body mass index [PDF]

Developmental Medicine & Child Neurology, 2015
This commentary is on the original article by Gutknecht et al. on pages 1070–1075 of this issue.
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source