Results 171 to 180 of about 5,650,064 (293)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Exercise-induced hypoalgesia in healthy males is best explained by mechanisms selectively affecting deep-tissue pain sensitivity within exercising body parts. [PDF]

Neurobiol Pain
Aron V, Graven-Nielsen T, Deldicque L, Mouraux A.   +3 more
europepmc   +1 more source

A multidimensional sensory evaluation model to investigate the (dis)comfort of body parts in a supine sitting position during a lunch break. [PDF]

Heliyon, 2023
Fu YL, Dai R, Xie X, Song W.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Research Note: Evaluation of microbial contamination on broiler carcasses - an investigation of body parts and sampling methods. [PDF]

Poult Sci
Wyink B, Kirse A, Reich F.
europepmc   +1 more source

Chimpanzees (Pan troglodytes) detect strange body parts: an eye-tracking study. [PDF]

Anim Cogn, 2022
Gao J, Adachi I, Tomonaga M.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Workers' Injury Risks Focusing on Body Parts in Reinforced Concrete Construction Projects. [PDF]

Int J Environ Res Public Health
Lim J, Cho J, Kim J, Kang S.
europepmc   +1 more source

Effect of cold ambient temperature on heat flux, skin temperature, and thermal sensation at different body parts in elite biathletes. [PDF]

Front Sports Act Living, 2022
Blokker T, Bucher E, Steiner T, Wehrlin JP.   +3 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source